研究

1. KMUP-1 衍生物之statin-like pleitropic 活性：降血脂，保肝及細胞生長抑制作用
   國科會99年度專題研究計畫(99/08/01~100/07/31)
2. KMUP-1對於肝臟缺血再灌流及缺氧引起損傷之保護作用
   國科會100年度專題研究計畫(100/08/01~101/07/31)
3. KMUP-1抑制STZ引起糖尿病大鼠腎絲球病變
   國科會101年度專題研究計畫(101/08/01~102/07/31)
4. 心肺系統血管內皮失能之新治療策略-心肺系統血管內皮失能之新治療策略(1/2)
   國科會101年度專題研究計畫(101/08/01~102/07/31)
5. 心肺系統血管內皮失能之新治療策略-心肺系統血管內皮失能之新治療策略(2/2)
   國科會102年度專題研究計畫(102/08/01~103/07/31)

著作

1. Hsu JH, Liou SF, Yang SN, Wu BN, Dai ZK, Chen IJ, Yeh JL, Wu JR. (2014 Aug) B-type natriuretic peptide inhibits angiotensin II-induced proliferation and migration of pulmonary arterial smooth muscle cells. Pediatr Pulmonol. 49(8):734-44.
2. Dai ZK, Lin TC, Liou JC, Cheng KI, Chen JY, Chu LW, Chen IJ, Wu BN. (2014 May) Xanthine derivative KMUP-1 reduces inflammation and hyperalgesia in a bilateral chronic constriction injury model by suppressing MAPK and NFκB activation. Mol Pharm. 11(5):1621-31.
3. Shen KP, Lin HL, Chang WT, Lin JC, An LM, Chen IJ, Wu BN. (2014 Mar) Eugenosedin-A ameliorates hyperlipidemia-induced vascular endothelial dysfunction via inhibition of α1-adrenoceptor/5-HT activity and NADPH oxidase expression. Kaohsiung J Med Sci. 30(3):116-24.
4. Hsu JH, Liou SF, Yang SN, Wu BN, Dai ZK, Chen IJ, Yeh JL, Wu JR. (2014 Aug) B-type natriuretic peptide inhibits angiotensin II-induced proliferation and migration of pulmonary arterial smooth muscle cells. Pediatr Pulmonol. 49(8):734-44.
5. Kuo HF, Lai YJ, Wu JC, Lee KT, Chu CS, Chen IJ, Wu JR, Wu BN. (2013 Dec) A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci. 10(1):64-72.
6. Liou SF, Hsu JH, Lin IL, Ho ML, Hsu PC, Chen LW, Chen IJ, Yeh JL*. (2013 July) KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy- Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways. PLoS One. 25; 8(7):e69468. doi: 10.1371/journal.pone.0069468.
7. Liu CM, Fan YC, Lo YC, Wu BN, Yeh JL, Chen IJ*. (2013 May) Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia. Int J Urol. 21(1):87-92.
8. Lin HL, Shen KP, Chang WT, Lin JC, An LM, Chen IJ, Wu BN. (2013 Feb) Eugenosedin-A prevents high-fat diet increased adhesion molecules through inhibition of MAPK- and p65-mediated NF-κB pathway in rat model. J Pharm Pharmacol. 65(2):300-9.
9. Yeh JL, Hsu JH, Liang JC, Chen IJ, Liou SF. (2013 Feb) Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities. Atherosclerosis. 226(2):364-72.
10. Yeh JL, Liu CP, Hsu JH, Tseng CJ, Wu PJ, Wang YY, Wu JR, Chen IJ*. (2012 Nov) KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin. Kaohsiung J Med Sci. 28(11):567-76.
11. Liou SF, Hsu JH, Liang JC, Ke HJ, Chen IJ, Wu JR, Yeh JL. (2012 Apr) San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia/ reoxygenation injury via inhibition of oxidative stress-induced apoptosis. J Nat Med. 66(2):311-20.
12. Liu CP, Hsieh CH, Wu BN, Yeh JL, Dai ZK, Chai CY, Chen IJ*. (2012 Aug) Inhaled KMUP-1 prevents allergic pulmonary vascular inflammation and remodeling via NO and suppressed MMP-9 and ICAM-1/VCAM-1. Inflamm Allergy Drug Targets. 11(4):251-61.
13. Chen JY, Cheng KI, Tsai YL, Hong YR, Howng SL, Kwan AL, Chen IJ, Wu BN*. (2012) Potassium Channel Openers KMUP-1 and Pinacidil Prevent Subarachnoid Hemorrhage-Induced Vasospasm by Restoring the BKCa Channel Activity. Shock. 38(2):203-12.
14. Wu BN, Chen HY, Liu CP, Hsu LY, Chen IJ*. (2011 Oct-Dec) KMUP-1 inhibits H441 lung epithelial cell growth, migration and proinflammation via increased NO/CGMP and inhibited RHO kinase/VEGF signaling pathways. Int J Immunopathol Pharmacol. 24(4):925-39.
15. Lin YL, Lin RJ, Shen KP, Dai ZK, Chen IJ, Wu JR, Wu BN. (2011 Nov) Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. J Ethnopharmacol. 138(2):373-81.
16. Liou SF, Ke HJ, Hsu JH, Liang JC, Lin HH, Chen IJ, Yeh JL. (2011) San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/ Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways. Evid Based Complement Alternat Med. 2011:915051.
17. Yeh JL, Hsu JH, Hong YS, Wu JR, Liang JC, Wu BN, Chen IJ, Liou SF. (2011) Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages. Int J Immunopathol Pharmacol. 24(2):345-56.
18. Chen JY, Jiang MC, Chu LW, Hsieh SL, Chen IJ, *Wu BN. (2011) KMUP-1 inhibits L-type Ca²⁺ channels involved the protein kinase C in rat basilar artery myocytes. Kaohsiung J Med Sci. 27(12):538-43.
19. Hsu JH, Wu JR, Liou SF, Chen HM, Dai ZK, Chen IJ, Yeh JL.(2011) Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis. Atherosclerosis 217(2):379-86.
20. Shen KP, Lin HL, Chang WT, An LM, Chen IJ, Wu BN. (2011) Suppression of inflammatory response and endothelial nitric oxide synthase downregulation in hyperlipidaemic C57BL/6J mice by eugenosedin-A. J Pharm Pharmacol. 63(6):860-8.
21. Chen IS, Dai ZK, Welsh DG, Chen IJ, Wu BN. (2011 Jan) Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells. J Biomed Sci. 18:2. doi: 10.1186/1423-0127-18-2.
22. Liu CP, Yeh JL, Wu BN, Chai CY, Chen IJ, Lai WT. (2011 ) KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance. Br J Pharmacol. 162(1):126-35.
23. Dai ZK, Cheng YJ, Chung HH, Wu JR, *Chen IJ, and *Wu BN (2010) KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel. Life Sciences 86: 747-755.
24. Lin YL, Dai ZK, Lin RJ, Chu KS, Chen IJ, *Wu JR, and *Wu BN (2010) Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. Phytomedicine 17(10):760-70.
25. Chung HH, Dai ZK, Wu BN, Yeh JL, Chai CY, Chu KS, Liu CP, *Chen IJ (2010) The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase. British Journal of Pharmacology 160(4):971-86.
26. Yeh JL, Hsu JH, Wu PJ, Liou SF, Liu CP, Chen IJ, Wu BN, Dai ZK, and Wu JR (2010) KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways. British Journal of Pharmacology159: 1151-1160.
27. Hsu YY, Liu CM, Tsai HH, Jong YJ, Chen IJ, Lo YC* (2010) KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways. Toxicology 268(1-2):46-54.
28. Liou SF, Lin HH, Liang JC, Chen IJ, Yeh JL.(2009). Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis.Toxicology 256(1-2):13-24.
29. Wu BN, Chen ML, Dai ZK, Lin YL, Yeh JL, Wu JR, Chen IJ*. (2009) Inhibition of voltage-gated L-type calcium channels by labedipinedilol-a involves protein kinase C in rat cerebrovascular smooth muscle cells. Vascul Pharmacol. 51(2-3):65-71.
30. Shen KP, Lin HL, Hsieh SL, Kwan AL, Chen IJ, Wu BN. (2009) Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet. J Pharm Pharmacol. 61(4):517-25.
31. Shih YT, Chen IJ, Wu YC, Lo YC. (2009) San-Huang-Xie-Xin-Tang Protects Against Activated Microglia- and 6-OHDA-induced Toxicity in Neuronal SH-SY5Y Cells. Evid Based Complement Alternat Med.
32. Liu CM, Lo YC, Tai MH, Wu BN, Wu WJ, Chou YH, Chai CY, Huang CH, Chen IJ*. (2009) Piperazine-designed alpha 1A/alpha 1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts. Prostate 69(6):610-23.
33. Wu JR, Liou SF, Lin SW, Chai CY, Dai ZK, Liang JC, Chen IJ, Yeh JL. (2009) Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling. Pharmacol Res. 59(1):48-56.

指導研究生

校內外榮譽

1. 100學年度本校研究傑出教師
2. 100學年度本校專利獲證傑出獎
3. 100學年度本校研究論文獎勵
4. 100學年度科技部補助大專校院獎勵特殊優秀人才
5. 101學年度本校研究論文獎勵
6. 101學年度科技部補助大專校院獎勵特殊優秀人才
7. 102學年度科技部補助大專校院獎勵特殊優秀人才
8. 102學年度技術移轉卓越獎