研究

著作

1. Chen SH, Chen CH, Lin HC, Yeh SA, Hwang TL*, Chen PJ*. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis. Journal of Advanced Research, 2025 Jun; 72: 485-500 (IF: 13)
2. Hemida N, El-Gamil DS, ElHady AK, Lin KC, Chang YH, Hilscher S, Schutkowski M, Ibrahim HS, Hamed MM, Chen SH, Chen CH, Abadi AH, Sippl W, Chen PJ*, Cheng YS, Abdel-Halim M*. Unlocking the potential of novel Tetrahydro-β-Carboline-based HDAC6 inhibitors for colorectal Cancer therapy: Design, synthesis and biological evaluation. Bioorganic Chemistry, 2025 Jun; 160: 108454.
3. Fathya A, Allama A, ElHady AK, El-Gamil DS, Lin KC, Chang YH, Lee YH, Hilscher S, Schutkowski M, Ibrahim HS, Chen SH, Chen CH, Abadi AH, Sippl W, Chen PJ*, Cheng YS, Abdel-Halim M*. Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer. RSC Medicinal Chemistry, 2025 Jun; 16: 2754.
4. Chang YH, Lee YC, Chen SH, Fang SY, Cheng TP, Chi CH, Tsai KC, Chen PJ*, Hung HY*. Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses. Biochemical Pharmacology, 2025 May; 235: 116806. (IF: 5.6)
5. Chen YC, Lee YR, Chang YC, Wang YH, Fang SY, Lin CH*, Chen PJ*, Hwang TL*. Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses. Journal of Ethnopharmacology, 2025 Apr; 346: 119653.
6. Kuo SL, Su CH, Lai KH, Chang YC, You JS, Peng HH, Chen CH, Lin CC*, Chen PJ*, Hwang TL*. Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice. Biomedical Journal, 2025 Feb; 48(1):100731.
7. Chen PJ, Chen SH, Chen YL, Wang YH, Lin CY, Chen CH, Tsai YF, and Hwang TL. Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. Journal of Advanced Research, 2024 Aug; 62:229-243. (IF: 13)
8. Mohamed NN^#, Chen PJ^#, Darwish SS, Su YC, Shiao MH, Gary A P, Abadi A, Engel M, Abdel-Halim M. N-benzylated 5-hydroxybenzothiophene-2-carboxamides as multitargeted Clk/Dyrk inhibitors and potential anticancer agents. Cancers, 2024 May; 16(11), 2033 
9. el-Rahman YAA^#, Chen PJ^#, ElHady AK, Chen SH, Lin HC, El-Gamil DS, Aboushady Y, Abadi1 AH, Abdel-Halim M, Engel M. Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future Medicinal Chemistry, 2024 May; 16(12):1239-1254.
10. Chen PJ, Tseng HH, Wang YH, Fang SY, Chen SH, Chen CH, Tsai SC, Chang YC, Tsai YF, and Hwang TL. Palbociclib blocks neutrophilic PI3K activity to alleviate psoriasiform dermatitis. British Journal of Pharmacology, 2023 Aug; 180(16):2172-88 (IF: 7.7)
11. Su YC, Lee WC, Wang CC, Yeh SA, Chen WH, and Chen PJ*. Targeting PI3K/AKT/mTOR signaling pathway as a radiosensitization in head and neck squamous cell carcinomas. International Journal of Molecular Sciences, 2022 Dec; 23(24), 15749.
12. Wagdy R^#, Chen PJ^#, Hamed MM^#, Darwish S, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors. Bioorganic Chemistry, 2022 Oct; 127, 105977. 
13. Darwish S^#, Chen PJ^#, Hamed MM^#, Wagdy R, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. Development of (4-phenylamino)quinazoline alkylthiourea derivatives as novel NF-κB inhibitors. Pharmaceuticals, 2022 Jun; 15(7), 778.
14. Chen YY^#, Chen LY^#, Chen PJ^#, El-Shazly M, Peng BR, Chen YC, Su CH, Su JH, Sung PJ, Yen PZ, Wang LS, Lai KH. Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209. Metabolites, 2022 Apr; 12(4), 320.
15. Kao TI^#, Chen PJ^#, Wang YH, Tseng HH, Chang SH, Wu TS, Yang SH, Lee YT, Hwang TL. Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity. British Journal of Pharmacology, 2021 Oct; 178(20):4069-4084. (IF: 7.7)
16. Lai KH^#, Chen PJ^#, Chen CC, Yang SH, El-Shazly M, Chang YC, Wu YH, Wu YH, Wang YH, Hsieh HL, Hwang TL. Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. Journal of Ethnopharmacology, 2021 Jan; 264:113224.
17. Chen PJ, Kuo LM, Lai KH, Chang YC, Wu YH, Hwang TL. BAY 41-2272 attenuates the TGFβ1-induced CTGF expression via sGC-independent pathway in hepatic stellate cells. Biomedicines; 2020 Sep; 8(9):330.
18. Liu FC^#, Yu HP^#, Chen PJ^#, Yang HW, Chang SH, Tzeng CC, Cheng WJ, Chen YR, Chen YL, Hwang TL. A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice. Redox Biology, 2019 Sep; 26:101273. (IF: 11.9)
19. Chen PJ, Ko IL, Lee CL, Hu HC, Chang FR, Wu YC, Leu YL, Wu CC, Lin CY, Pan CY, Tsai YF, Hwang TL. Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation. EBioMedicine, 2019 Feb; 40:528-40. (IF: 10.8)
20. Kuo LM^#, Chen PJ^#, Sung PJ, Chang YC, Ho CT, Wu YH, Hwang TL. The bioactive extract of Pinnigorgia sp. induces apoptosis of hepatic stellate cells via ROS-ERK/JNK-caspase 3 signaling. Marine Drugs, 2018 Jan; 16(1):19-31.
21. Chen PJ, Wang YL, Kuo LM, Lin CF, Chen CY, Tsai YF, Shen JJ, Hwang TL. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα. Scientific Reports, 2016 May; 23(6):26554.
22. Chen PJ, Weng JY, Hsu PH, Shew JY, Huang YS, Lee WH. NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress. Nucleic Acids Research, 2015 Oct; 43(19):9393-404. (IF: 13.1)
23. Chen PJ, Huang YS. CPEB2-eEF2 interaction impedes HIF-1α RNA translation. EMBO Journal, 2012 Feb; 31(4):959-71. (IF: 8.3)

研討會論文

1. Chen PJ*, Chen SH, Hung HY, and Lee YC. Discovery of a novel formyl peptide receptor 1 antagonist for treating neutrophilic inflammation. The 39^th Joint Annual Conference of Biomedical Science, Taiwan, 2025
2. Chen PJ*. Bletilla formosana and its constituents as promising therapeutics via modulation of redox homeostasis. 2025中醫藥與天然藥物聯合學術研討會, 2025 (受邀演講)
3. Chen PJ*. Advancing the development of drug candidates for neutrophilic inflammatory diseases. 第三十九屆生物醫學聯合學術年會台灣藥理學會, 2025 (受邀演講)
4. Chen SH, Chen CH, Hsu CL, Chang YC, and Chen PJ*. Natural bibenzyl exerts mitotic inhibition in the treatment of nasopharyngeal carcinoma. The 145^th Annual Meeting of the Pharmaceutical Society of Japan, Fukuoka, Japan, 2025
5. Tsai SC, Lee CH, Hong YC, Liu HH, Lai KH, Lam SH, and Chen PJ*. Pholidota chinensis-derived dihydrophenanthrene prompts GPx4 inhibition and ferroptotic oxidative stress for treating colorectal cancer. The 39^th Symposium on Natural Products and 24^th Society for Free Radical Research-Taiwan, Taiwan, 2024 (Best Poster Award)
6. Lai IJ, Lee YC, Hung LY, Yeh CJ, Liu HH, Lai KH, Chang YC, and Chen PJ*. Exploring prevention of body fat accumulation in traditional Chinese medicine from Rubiaceae. The 39^th Symposium on Natural Products and 24^th Society for Free Radical Research-Taiwan, Taiwan, 2024
7. Kuo SL, Lin CC, Chen PJ*, and Hwang TL. Guizhi Fuling Wan employs antiapoptotic, antioxidant, and immunomodulatory protection against concanavalin A-induced autoimmune hepatitis in mice. The Society for Free Radical Research-Taiwan, Taiwan, 2023 (Best Poster Award)
8. Chen PJ*, Chen SH, and Hwang TL. Drug repurposing of ribociclib in the treatment of inflammatory disease. The 19^th World Congress of Basic and Clinical Pharmacology, Glasgow, UK, 2023
9. Chen PJ*, Chen SH, Sie JY, and Hwang TL. The effects of a pure compound from Bletilla in the treatment of acute liver injury. The 37^th Joint Annual Conference of Biomedical Science, Taiwan, 2023
10. Huang YT, Lee YC, Chang YC, Chen PJ*. Development of anticancer marine products in colorectal cancer. The 37^th International Symposium on Natural Products, The Society of Chinese Natural Medicine, Taiwan, 2022
11. Tsai SC, Chen SH, Chen PJ*, and Hwang TL. CDK inhibitor serves as a new drug for treatment of neutrophilic psoriasiform dermatitis. The 36^th Joint Annual Conference of Biomedical Science, Taiwan, 2022 (Distinguished Poster Prize of Tien Te Lee Biomedical Foundation)
12. Chen PJ*. Recent advance in targeting inflammatory diseases. 中山醫學大學2021年基礎與應用科學和創新與創業研討會, 2021 (受邀演講)
13. Chen PJ*, Chen SH, Tseng HH, and Hwang TL. CDK inhibitor ameliorates neutrophil-associated psoriasiform dermatitis by inhibiting PI3K activity. 14^th Asia Pacific Federation of Pharmacologists, Pharmacological Society in Taiwan, Taiwan, 2021
14. Chen PJ, Kao TI, and Hwang TL. Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity. 14^th Asia Pacific Federation of Pharmacologists, Pharmacological Society in Taiwan, Taiwan, 2021
15. Chen PJ*. Opportunity of anti-inflammatory agents on cosmetics for skin disorders第十五屆亞洲化粧品科學家大會 (ASCS Conference), 2021 (受邀演講)
16. Chen PJ, Lai KH, and Hwang TL. Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. The 35^th International Symposium on Natural Products, The Society of Chinese Natural Medicine, Taiwan, 2020 (Poster Award)
17. Chen PJ and Hwang TL. A novel PDE4 inhibitor impedes psoriasis-like lesions via restricting neutrophilic inflammation. 16^th International Workshop on Langerhans Cells, Mainz/Budenheim, Germany, 2019
    European Journal of Immunology. 2019; 49 (Suppl. 2): 1–28
18. Chen PJ and Hwang TL. A novel NOX2 inhibitor CYR5099 attenuates neutrophilic oxidative stress and inflammatory paw injury in mice. The 18^th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 2018
19. Chen PJ, Lee CL, Chang FR, Wu YC, and Hwang TL. Targeting redox regulatory site of protein kinase B impedes neutrophilic inflammation. The 32^nd International Symposium on Natural Products, The Society of Chinese Natural Medicine, Taiwan, 2017 (Best Poster Award)
20. Chen PJ and Huang YS. CPEB2 interacts with eEF2 and impedes target RNA translation at elongation. The 16^th Annual Meeting of the RNA Society, Kyoto, Japan, 2011 (Poster Award)

指導研究生

校內外榮譽