楊玉嬌 副教授 (Yang, Yu-Chiao)
- 電話：+886-7-3121101 ext.2139 #13、11
- 傳真：+886-7-3234686
- 信箱：m755016@kmu.edu.tw；ycyang230@gmail.com
- 學歷：
- 高雄醫學大學 醫學研究所 博士
- 高雄醫學大學 醫學研究所 碩士
- 高雄醫學大學 藥學系 學士
- 研究專長：藥理學、藥學、中草藥研究、抗癌藥物研發
- 研究方向：
- 中草藥研究
- 抗癌藥物研發
教學
主負責專業課程
- 碩士班二年級：中草藥及新藥之抗癌研發特論
- 碩士班一年級：臨床新藥之研發特論
參與其他專業課程
- 醫學系、後醫學系：block 課程
- 牙醫學系三年級：藥理學(含牙科藥理學)、藥理學實驗
- 藥學系三年級：藥理學、藥理學實驗
- 護理學系二年級：藥理學
研究
- Cognitive Improvement Effects of Eclipta prostrata
107 高醫(種子計畫)(108/01/01~108/12/31) - Ameliorating effects of Morus nigra on learning and memory
105 高醫(種子計畫)(106/01/01~106/12/31) - 半枝蓮黃酮類抗腫瘤成分工業大量製造之適化抽取條件研究
103 高醫(種子計畫)(104/01/01~104/12/31) - 植物水萃取液對動物毛髮增生之活性檢測
102年度產學合作計畫(103/01/01~103/12/31) - 中草藥抽取動力學之研究
102年度產學合作計畫(102/12/01~103/09/30) - 最適化中藥製成之研究
102年度產學合作計畫(102/12/01~103/09/30)
著作
- M.C. Wei #, W.L. Lee#, P.H. Huang #, D.H. Wei, Z.S. Jheng, Yang YC*. Programming and validation of a novel green procedure for the production of essential oil from Lavandula angustifolia. FOOD AND BIOPRODUCTS PROCESSING. 2024 145:239-249.
- Wei MC, Wang CS, Liou RM, Yang YC*. Development and validation of a green and sustainable procedure for the preparation of Perilla frutescens extracts. Food Chem. 2022 Feb 1;369:130929.
- Yang YC, Wang CS*, Wei MC*. Validation of a greener procedure for the extraction of triterpenic acids from Hedyotis corymbosa. Microchem. J. 2021 Jun, 165, 106062.
- Yang YC, Wang CS, Wei MC*. Insights into the major phenolic acids in Perilla frutescens obtained by a sustainable procedure. J. Ind. Eng. Chem. 2021 in press.
- Wei MC, Wang CS, Wei DH, Yang YC*. Insights into the supercritical CO2 extraction of perilla oil and its theoretical solubility. Processes. 2021 Feb, 9, 239.
- Yang YC, Wang CS, Wei MC * A green approach for the extraction and characterization of oridonin and ursolic and oleanolic acids from Rabdosia rubescens and its kinetic behavior. Food Chem. 2020 Jul 30, 319, 126582.
- Yang YC, Wang CS, Wei MC * Development and validation of an ultrasound-assisted supercritical carbon-dioxide procedure for the production of essential oils from Perilla frutescens. LWT-Food Sci Technol. 2020 Jun, 128, 109503.
- Yang YC, Wang CS, Wei MC *Kinetics and mass transfer considerations for an ultrasound-assisted supercritical CO2 procedure to produce extracts enriched in flavonoids from Scutellaria barbata. J CO2 Util. 2019 Jul, 32, 219-231.
- Yang YC, Wang CS, Wei MC * Separation and quantification of bioactive flavonoids from Scutellaria barbata using a green procedure. Food and Bioprod Process. 2019 Nov, 118, 77-90.
- Yang YC,Wei MC. Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. Food Chem. 2018 Jun 30;252:381-389.
- Teng, H, Lin, QY, Li, K, Yuan, BY, Song, HB, Peng, HQ, Yi, LZ, Wei, MC, Yang YC, Battino, M, Acuna, CLC , Chen, L, Xiao, JB* Regulatory efficacy of brown seaweed lessonia nigrescens extract on the gene expression profile and intestinal microflora in type 2 diabetic mice. Mol Nutr & Food Res. 2018 Feb, 62(4), 1700730
- Teng H, Lin Q, Li K, Yuan B, Song H, Yi LZ, Wei MC, Yang YC, Battino M, Acuña CLC, Chen L, Xiao JB. Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. Food Chem. Toxicol. 2017 Dec, 110, 418-424.
- Wei MC., Hong SJ., Yang YC* Isolation of triterpenic acid-rich extracts from Hedyotis corymbosa using ultrasound-assisted supercritical carbon dioxide extraction and determination of their fictitious solubilities. J Ind Eng Chem. 2017 Apr 25, 48, 202-211
- Yang YC, Wei MC. Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. Food Chem. 2018 Jun 30; 252:381-389.
- Yang YC, Wei MC, Hong SJ. Evaluation of occupation hot exposure in industrial workplaces in a subtropical country. Int J Occup Med Environ Health. 2017 May 8; 30(3):379-395.
- Yang YC, Lin PH, Wei MC. Production of oridonin-rich extracts from Rabdosia rubescens using hyphenated ultrasound-assisted supercritical carbon dioxide extraction. J Sci Food Agric. 2017 Aug; 97(10):3323-3332.
- Wei MC, Xiao J, Yang YC*. Extraction of α-humulene-enriched oil from clove using ultrasound-assisted supercritical carbon dioxide extraction and studies of its fictitious solubility. Food Chem. 2016 Nov 1; 210:172-81.
- Wu KY, Lai YH, Yang YC, Wu WC, Hong SJ. 5-Fluorouracil-Induced Apoptosis Changes in Cultured Corneal Epithelial Cells. J Ocul Pharmacol Ther. 2016 Apr; 32(3):155-62.
- Wei MC, Lin PH, Hong SJ, Chen JM, Yang YC * Development of a green alternative procedure for simultaneous separation and quantification of clove oil and its major bioactive constituents. ACS Sustain. Chem Eng. 2016 Dec, 4(12), 6491-6499.
- Yang YC, Wei MC*, A combined procedure of ultrasound-assisted and supercritical carbon dioxide for extraction and quantitation oleanolic and ursolic acids from Hedyotis corymbosa. Ind Crop Prod. 2016 Jan, 79, 7-17.
- Wei MC, Yang YC*, Hong SJ. Determination of Oleanolic and Ursolic Acids in Hedyotis diffusa Using Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography. Evid Based Complement Alternat Med. 2015; 2015:450547.
- Yang YC*, Wei MC, Ethanol solution-modified supercritical carbon dioxide extraction of triterpenic acids from Hedyotis corymbosa with ultrasound assistance and determination of their solubilities. Sep Purif Technol. 2015 Aug 17, 150, 204-214.
- Wei MC, Yang YC*, Kinetic studies for ultrasound-assisted supercritical carbon dioxide extraction of triterpenic acids from healthy tea ingredient Hedyotis diffusa and Hedyotis corymbosa. Sep Purif Technol. 2015 Mar 4, 142, 316-325.
- Yang YC, Wei MC *, Kinetic and characterization studies for three bioactive compounds extracted from Rabdosia rubescens using ultrasound. Food and Bioprod Process. 2015 Apr, 94, 101-113.
- Su YF, Yang YC, Hsu HK, Hwang SL, Lee KS, Lieu AS, Chan TF, and Lin CL. Toona sinensis leaf extract has antinociceptive effect comparable with non-steroidalanti- inflammatory agents in mouse writhing test. BMC Complement Altern Med. 2015 Mar 19, 15, 70.
- Yang YC, Wei MC, Hong SJ. Ultrasound-assisted extraction and quantitation of oils from Syzygium aromaticum flower bud (clove) with supercritical carbon dioxide. J Chromatogr A. 2014 Jan 3; 1323:18-27.
- Wei MC, Yang YC*, Extraction characteristics and kinetic studies of oleanolic and ursolic acids from Hedyotis diffusa under ultrasound-assisted extraction conditions. Sep Purif Technol., 2014 Jun 10, 130, 182-192.
- Yang YC, Wei MC*, Lian FY, Huang TC, Simultaneous extraction and quantitation of oleanolic acid and ursolic acid from Scutellaria barbata D. Don by ultrasound-assisted extraction and high-performance liquid chromatography. Chem Eng Commun. 2014 Apr 3, 201(4), 482-500.
- Yang YC, Wei MC, Chiu HF, Huang TC. Development and validation of a modified ultrasound-assisted extraction method and a HPLC method for the quantitative determination of two triterpenic acids in Hedyotis diffusa. Nat Prod Commun. 2013 Dec; 8(12):1683-6.
- Yang YC, Wei MC*, Hong SJ, Huang TC, Lee SZ. Development/optimization of a green procedure withultrasound-assisted improved supercritical carbon dioxide to produceextracts enriched in oleanolic acid and ursolic acid from Scutellariabarbata D. Don. Industrial Crops and Products. 2013 Jul; 49(1):542-553.
- Wei MC, Yang YC, Chiu HF, Hong SJ. Development of a hyphenated procedure of heat-reflux and ultrasound-assisted extraction followed by RP-HPLC separation for the determination of three flavonoids content in Scutellaria barbata D. Don. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 1; 940:126-34.
- Yang YC, Wei MC*, Huang TC, Lee SZ, Lin SS. Comparison of modified ultrasound-assisted and traditional extraction methods. Industrial Crops and Products. 2013 Feb; 45(1): 182-190.
- Yang YC, Wei MC*, Huang TC, Lee SZ. Extraction of protocatechuic acid from Scutellaria barbata D. Don using. Journal of Supercritical Fluids. 2013 Jun; 81( 1):55-66.
- Yang YC, Wei MC, Huang TC. Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. Phytochem Anal. 2012 Nov-Dec; 23(6):627-36..
- Cheng MH, Yang YC, Wong YH, Chen TR, Lee CY, Yang CC, Chen SH, Yang IN, Yang YS, Huang HS, Yang CY, Huang MS, Chiu HF*. B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells. Anticancer Drugs. 2012; 23(2):191-9.
研討會論文
- Yang YC, Lee WL, Lin CC, Wei DH, Wei MC*. (2023) Development and Application of an Ultrasound-Assisted Supercritical Co2 Procedure for the Production of Rosmarinus Officinalis Oil. 2023 6th International Conference on Mathematics and Statistics. Germany/Leipzig.(Oral Speaker)
- Yang YC, Hong SJ, Wei DH, Lin PH, Wei MC*. (2019) Production of essential oil from Lavandula angustifolia through a green procedure and its theoretical solubility consideration. UK Fluids Conference 2019, Cambridge, UK. (Invited Speaker)
- Wei MC, Hong SJ, Wei DH, Lin PH, Yang YC*. (2019) Development and verification a green approach towards isolating essential oils from Rosmarinus officinalis using ultrasound-assisted supercritical CO2. UK Fluids Conference 2019, Cambridge, UK. (Invited Speaker)
- Wei MC, Hong SJ, Wei DH, Lin PH, Yang YC*. (2019) Thermal radiation hazard evaluation of workers in five workplaces. The 16th InternationalCongress of Radiation Research 2019 Conference, Manchester, UK. (Poster)
- Wei MC, Hong SJ, Wei DH, Lin PH, Yang YC*. (2019) Development a green approach towards isolating essential oils from Rosmarinus officinalis using ultrasonic radiant energy assisted supercritical CO2. The 16th InternationalCongress of Radiation Research 2019 Conference, Manchester, UK. (Poster)
- Yang YC, Hong SJ, Wei DH, Lin PH, Wei MC*. (2019) Production of essential oil from Lavandula angustifolia using ultrasonic radiant energy assisted supercritical CO2 and its theoretical solubility consideration. The 16th InternationalCongress of Radiation Research 2019 Conference, Manchester, UK. (Poster)
- Wei MC, Hong SJ, Hui-fen Chiu, Pei-Hui Lin, Yang YC*. (2018) Development and validation of a green procedure for production of three key bioactive compounds from a herbal tea. European Biological Inorganic Chemistry Conference.Birmingham, UK. (Poster)
- Yang YC, Chiu HF, Wei DH, Hong SJ, Lin PH, Wei MC*. (2018) Separation and quantification of rosmarinic acid from herbal medicine using a green alternative procedure. European Biological Inorganic Chemistry Conference.Birmingham, UK. (Poster)
- Wei MC, Xiao J, Chiu HF, Hong SJ, Wei DH, Lin PH, Yang YC*. (2018) Development a green approach towards isolating essential oils from Rosmarinus officinalis using ultrasonic radiant energy assisted supercritical CO2. European Biological Inorganic Chemistry Conference, Birmingham, UK. (Poster)
- Yang YC, Xiao J, Hong SJ, Chiu HF, Wei DH, Lin PH, Wei MC*. (2018) Design and characterization of a green alternative procedure for the production of extracts rich in Perilla frutescens oils. 3rd International Symposium on Phytochemicals in Medicine and Food, Kunming, China. (Poster)
- Wei MC, Hong SJ, Chiu Hf, Lin PH and Yang YC*. (2018) Development and validation of a green procedure for production of three key bioactive compounds from a herbal tea. 3rd International Symposium on Phytochemicals in Medicine and Food, Kunming, China. (Poster)
- Lin WT, Wong YH, Valens Munyembaraga, Lin YC, Yang CC, Chen YC, Yang YC, Hong SJ, Chiu HF*. (2018) Fucoidan induced cell apoptosis may through generation of ROS and disruption of mitochondrial membrane potential in human renal cancer cells. The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan. (Poster)
- Yang CC, Chang CM, Wong YH, Cheng MH, Yang YC, Kuo HM, Yuan CL, Hong SJ, Chiu HF*. 18th World Congress of Basic and Clinical Pharmacology (WCP 2018). Japan/Kyoto. (Poster)
- Lin YC, Wong YH, Valens Munyembaraga, Lin1 WT, Chen YC, Yang YC, Chiu HF*. (2018) Fucoidan induced apoptosis may through STAT3 and NF-κB regulation in human lung cancer cells. The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan. (Poster)
- Yang YC, Hong SJ, Lin PH, Wei MC∗. (2017) Development of a green alternative procedure for simultaneous separation and quantification of phytochemicals. International Science and Technology America Conference. America/Boston. (Invited Speaker)
- Yang YC, Hong SJ, Lin PH, Wei MC*. (2017) Production of eugenyl acetate-enriched oil from clove using ultrasound-assisted supercritical carbon dioxide extraction. 20th Annual Enerngy, Utility & Enviroment. America/San Diego. (Invited Speaker)
- Wei MC, Lin PH, Hong SJ, Yang YC*. (2016). Extraction kinetics of ultrasound-assisted extraction of oleanolic acid from Hedyotis corymbosa. 11th International Conference on Mass Data Analysis of Images and Signals. United States of America/New York. (Invited Speaker)
- Yang CC, Chang CM, Wong YH, Cheng MH, Yang YC, Kuo HM, Yuan CL, Hong SJ, Chen CY, Chiu HF*. (2016). Anandamide induced human hepatoma cells death through the DNA damage and apoptosis induction.15th Meeting of Consortium for Globalization of Chinese Medicine. Taiwan/Taipei (Poster)
- Yang YC*. (2015). Supercritical carbon dioxide extraction of ursolic acid from Rabdosia rubescens assisted by ultrasound and its solubility determination. International Symposium on Phytochemicals in Medicine and Food (ISPMF 2015). China/Shanghai. (Invited Speaker)
- Yang CC, Chang CM, Lee CW, Wu KH, Wong YH, Cheng MH, Yang YC, Kuo HM, Yuan CL, Hong SJ, Chen CY, Chiu HF. (2015). Anandamide induced cell cycle arrest through the DNA damage and inhibition of telomerase activity in human hepatoma cells. The 30th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei (Poster)
- Yang YC*. (2014). Extraction characteristics of oleanolic and ursolic acids from Hedyotis diffusa under ultrasound-assisted supercritical carbon dioxide extraction. AnalytiX-2014. China/Dalian (Invited Speaker)
- Yang YC*. (2014). Extraction characteristics of oridonin from Rabdosia rubescens enhanced via ultrasoun. IBIO-2014. China/Dalian (Invited Speaker)
- Yang CC, Chang CM, Chen CY, Wong YH , Cheng MH, Lin TH, Yang YC, Kuo HM, Yuan CL, Hong SJ, Chiu HF. (2014). Anandamide induced apoptosis through the ROS generation and DNA damage in human hepatoma cells. The 29thJoin Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster
- Chen CY, Chang CM, Yang CC, Wong YH, Cheng MH, Yu TH, Yang YC, Yuan CL, Kuo HM, Hong SJ, Chiu HF. (2014). C-phycocyanin induced anti-proliferation and angiogenesis repression in human hepatoma cell. The 29th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Wong YH, Chiang YW, Yang CC, Chang CM, Chen CY, Cheng MH, Yang YC, Kuo HM, Yuan CL, Hong SJ, Chiu HF. (2014). Bullatacin cause cell cycle G1 arrest in human hepatoma cells may through the regulation of STAT3 and NF-κB. The 29th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Chang CM, Chen CY, Yang CC, Wong YH, Cheng MH, Yang IN, Yang YC, Yuan CL, Kuo HM, Hong SJ, Chiu HF. (2014). B7, a novel anthraquinone derivative, cause cell cycle G1 arrest through cyclin D/E and cyclin dependent kinases 2/4 (CDK 2/4) inhibition in human hepatoma cells. The 29th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Chen SY, Shiu WC, Yang YC, Chen IJ, Wu BN. (2013). KMUP-1 lessens neuropathic pain via inhibition of PKA and PKC pathways in the dorsal root ganglion. The 28th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Hsu WC, Chen SY, Chu LW, Yang KT, Yang YC, Wu BN. (2013) KMUP-1 ameliorates neuropathic pain via inhibition of ERK and NF-kappaB pathways in the dorsal horn of spinal cord. The 28th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Yang CC, Yang YC, Cheng MH, Wong YH, Chen SH, Chiang YW, Chang CM, Chen CY, Kuo HM, Yuan CL, Chiu HF. (2013). The regulation of the STAT3 in AEA induced hepatoma cell apoptosis. The 28th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
- Chiang YW, Chen SH, Chang CM, Wong YH, Cheng MH, Chen CY, Liao KH, Yang CC, Yang YC, Yuan CL, Kuo HM, Hong SJ, Chiu HF. (2013) Bullatacin induces apoptosis through the regulation of Fas, Caspase 8/9 and Bax/Bcl-2 protein expression in human hepatoma cell. The 28th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
校內外榮譽
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112-2 學年度課程評量績優(有效平均值，5.40分(含)以上)
- 榮獲本校2022年優秀論文獎
- 榮獲本校111學年度績優導師暨輔導老師-績優書院導師
- 榮獲本校111年研究績優教師-優秀論文獎
- 榮獲本校2021年優秀論文獎
- 榮獲本校2020年研究成果績優獎
- 榮獲本校2020年優秀論文獎
- 榮獲本校2019年優秀論文獎
- 榮獲本校2019年研究成果績優獎
- 107 年度本校研究成果績優獎一般教師組
- 107-2 課程評量績優(有效平均值 5.40 分（含）以上)
- 107 學年度優秀論文獎
- 107-1 學期課程評量優良(有效平均值5.00分(含)~5.24分)
- 106 年度本校研究成果績優獎一般教師組
- 106-2 學期課程評量傑出 (有效平均值5.50(含)以上)
- 105 學年度研究成果績優教師
- 105 學年度優秀論文獎
- 105 學年度課程評量優良 (有效平均值5.0以上)
- 105 學年度教師教學評量特優(有效平均值5.25~5.49)