研究

1. 探討補骨脂寧用於牙周炎和停經後骨質疏鬆齧齒動物模型對發炎性骨損壞和蝕骨細胞過度活化之治療劑 (3年) 
   國科會112年專題研究計畫 (112/08/01~115/07/31)
2. 甘草素衍生物的抗發炎和抗蝕骨細胞新生作用可減緩實驗性牙周炎之研究 
   前瞻重點研究計畫 (113/01/01~113/12/31)
3. 探討茶鹼衍生物減緩實驗性關節炎的分子機轉研究
   前瞻重點研究計畫 (112/01/01~112/12/31)
4. 探討茶鹼衍生物抑制破骨細胞生成和牙周炎引起的牙槽骨破壞的治療機轉 (3年) 
   科技部109年專題研究計畫 (109/08/01~112/07/31)
5. 黃芩素及類似物對腹主動脈瘤和粥狀動脈硬化調節粒腺體動態和自噬作用的機轉探討(3年)
   科技部106年專題研究計畫 (106/08/01~109/07/31)
6. 探討黃芩素抑制血管收縮素II誘導腹主動脈瘤的分子機轉
   高奇合作計畫 (105/05/01~106/04/30)
7. 探討茶鹼衍生物誘導心肌細胞自體吞噬行為之心臟保護機轉(3年)
   科技部102年度專題研究計畫(102/08/01~105/07/31)
8. 探討鄰酸二酯酶抑制對蝕骨細胞新生作用之分子調控機制(3年)
   國科會99年度專題研究計畫(99/08/01~102/07/31)
9. a-Solanine在血管平滑肌細胞引起細胞凋亡的分子機轉研究
   財團法人屏東基督教醫院研究計畫(100/03/01~101/02/28)
10. 龍葵鹼引起心臟毒性的分子機轉研究
    財團法人屏東基督教醫院研究計畫(101/03/01~102/02/28)

著作

1. Huang SE, Hsu JH, Shiau BW, Liu YC, Wu BN, Dai ZK, Liu CP, Yeh JL*. Optimizing myocardial cell protection with xanthine derivative KMUP-3 potentiates autophagy through the PI3K/Akt/eNOS axis. Basic Clin Pharmacol Toxicol. 2024 Jun;134(6):818-832.
2. Dai ZK, Chen YC, Hsieh SL, Yeh JL, Hsu JH, Wu BN*. The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca²⁺ Entry in Pulmonary Arterial Smooth Muscle Cells. Pharmaceuticals (Basel). 2024 Mar 29;17(4):440.
3. Liu YC, Tseng YH, Kuan YH, Wang LY, Huang SE, Tsai SP, Yeh JL, Hsu JH. Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells. Kaohsiung J Med Sci. 2024 Apr 29. doi: 10.1002/kjm2.12835.
4. Sulistyowati E, Huang SE, Cheng TL, Chao YY, Li CY, Chang CW, Lin MX, Lin MC, Yeh JL*. Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress. Int J Mol Sci. 2023 Nov 6;24(21):16004. 
5. Wu YC, Wang WT, Yang MC, Su YT, Yeh JL, Hsu JH, Wu JR. The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension. Biol Res. 2023 Dec 7;56(1):66. doi: 10.1186/s40659-023-00480-z
6. Yeh JL, Kuo CH, Shih PW, Hsu JH, I-Chen P, Huang YH. Xanthine derivative KMUP-1 ameliorates retinopathy. Biomed Pharmacother. 2023 Sep;165:115109. 
7. Huang SE, Kuo CH, Shiao SY, Shen CR, Lee FT, Chang BI, Hsu JH, Wu HL, Yeh JL, Lai CH. Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases. Theranostics. 2023 Jul 14;13(12):4059-4078. 
8. Yen PT, Huang SE, Hsu JH, Kuo CH, Chao YY, Wang LS, Yeh JL*. Anti-Inflammatory and Anti-oxidative Effects of Puerarin in Postmenopausal Cardioprotection: Roles of Akt and Heme Oxygenase-1. Am J Chin Med. 2023;51(1):149-168.
9. Lai YW, Wu SH, Chou PR, Lin C, Yeh JL, Lin TM, Chai CY, Hsieh MW, Huang SH. Autologous Fat Grafting in Female Genital Area Improves Sexual Function by Increasing Collagenesis, Angiogenesis, and Estrogen Receptors. Aesthet Surg J. 2023 Feb 28:sjad040. doi: 10.1093.
10. Sulistyowati E, Hsu JH, Lee SJ, Huang SE, Sihotang WY,Wu BN, Dai ZK, Lin MC, Yeh JL*. Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo. Int J Mol Sci. 2022 May 18;23(10):5673. 
11. Wang LS, Yen PT, Weng SF, Hsu JH, Yeh JL. Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study.Medicina (Kaunas). 2022 Jun 30;58(7):879.
12. Kuo CH, Zhang BH, Huang SE, Hsu JH, Wang YH, Nguyen TTN, Lai CH, Yeh JL. Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation. Front Pharmacol. 2022 Apr 28;13:821492.
13. Hsieh MW, Wang WT, Yeh JL, Lin CY, Kuo YR, Lee SS, Hou MF, Wu YC. The Potential Application and Promising Role of Targeted Therapy in Pulmonary Arterial Hypertension. Biomedicines. 2022 Jun 15;10(6):1415.
14. Hsu HW, Lin TY, Liu YC, Yeh JL, Hsu JH. Molecular Mechanisms Underlying Remodeling of Ductus Arteriosus: Looking beyond the Prostaglandin Pathway. Int J Mol Sci. 2021 Mar 22;22(6):3238.
15. Cheng KI, Chen SL, Hsu JH, Cheng YC, Chang YC, Lee CH, Yeh JL, Dai ZK, Wu BN*. Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. Phytomedicine. 2021 Nov;92:153734. 
16. Huang SE, Sulistyowati E, Chao YY, Wu BN, Dai ZK, Hsu JH, Yeh JL*. In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis. Biomedicines. 2021 May 28;9(6):615.
17. Hung YC, Liu YC, Wu BN, Yeh JL, Hsu JH. Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats. Front Physiol. 2021 Jul 29;12:661171.
18. Cheng KI, Yang KT, Kung CL, Cheng YC, Yeh JL, Dai ZK, Wu BN*. BKCa Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia. Cells. 2021 Apr 20;10(4):949.
19. Lin TY, Yeh JL, Hsu JH. Role of Extracellular Matrix in Pathophysiology of Patent Ductus Arteriosus: Emphasis on Vascular Remodeling. Int J Mol Sci. 2020 Jul 4;21(13):4761. doi: 10.3390/ijms21134761.
20. Jan RL, Yang SC, Liu YC, Yang RC, Tsai SP, Huang SE,Yeh JL, Hsu JH. Extracellular heat shock protein HSC70 protects against lipopolysaccharide-induced hypertrophic responses in rat cardiomyocytes. Biomed Pharmacother. 2020 Aug;128:110370. doi: 10.1016/j.biopha.2020.110370. Epub 2020 Jun 7.
21. Lai CH, Chang CW, Lee FT, Kuo CH, Hsu JH, Liu CP, Wu HL, Yeh JL*. Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice. Atherosclerosis. 2020 Mar;297:16-24. 
22. Chu LW, Cheng KI, Chen JY, Cheng YC, Chang YC, Yeh JL, Hsu JH, Dai ZK, Wu BN. Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination. Phytomedicine. 2020 Feb;67:153166. doi: 10.1016/j.phymed.2019.153166. Epub 2019 Dec 30.
23. Lai CH, Chang CW, Lee FT, Kuo CH, Hsu JH, Liu CP, Wu HL, Yeh JL*.  Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice. Data Brief. 2020 Apr 19;30:105550. doi: 10.1016/j.dib.2020.105550. eCollection 2020 Jun.
24. Wu YC, Wang WT, Lee SS, Kuo YR, Wang YC, Yen SJ, Lee MY, Yeh JL*. Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways. Int J Mol Sci. 2019 Jul 12;20(14).
25. Lee ML, Sulistyowati E, Hsu JH, Huang BY, Dai ZK, Wu BN, Chao YY, Yeh JL*. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019 Apr 8;24(7). 
26. Lin SL, Yeh JL, Tsai PC, Chang TH, Huang WC, Lee ST, Wassler M, Geng YJ, Sulistyowati E. Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene. Transl Stroke Res. 2019 Aug;10(4):413-427. 
27. Hung YC, Yeh JL, Hsu JH.Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure. Int J Mol Sci. 2018 Jun 25;19(7).
28. Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH, Wu BN. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells. Chem Biol Interact. 2018 Jan 5;279:171-176.
29. Sulistyowati E, Hsu JH, Cheng YB, Chang FR, Chen YF, Yeh JL. Indonesian herbal medicine prevents hypertension-induced left ventricular hypertrophy by diminishing NADPH oxidase-dependent oxidative stress. Oncotarget. 2017 Sep 30;8(49):86784-86798.
30. Chen IC, Tan MS, Wu BN, Chai CY, Yeh JL, Chou SH, Chen IJ, Dai ZK. Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase. Pediatr Pulmonol. 2017 Apr;52(4):443-457. 

研討會論文

1. Jwu-Lai Yeh*, Rui-Yu Liao, Shang-En Huang, Meng-Xuan Lin. Exploring the Inhibitory Effect of Corylin on Porphyromonas gingivalis Lipopolysaccharide-Induced Experimental Periodontitis. The 7th International Conference and Exhibition on Pharmaceutical Sciences and Technology (PST 2024). Chiang Mai, Thailand (Poster)
2. Siao-Pei Hu, Meng-Xuan Lin, Shang-En Huang, Jwu-Lai Yeh*. (2024) Exploring the Inhibitory Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid on RANKL-Induced Osteoclastogenesis. 第38屆生物醫學聯合學術年會. 台北 (Poster)
3. Ling-Huei Luo, Siao-Ping Tsai, Shu-Hsuan Lin, Shang-En Huang, Jwu-Lai Yeh*. (2024) Mangiferin Attenuated Vascular Calcification in Rat Aortic Smooth Muscle Cells. 第38屆生物醫學聯合學術年會. 台北 (Poster)
4. Shang-En Huang, Jwu-Lai Yeh*, Chao-Han Lai*. (2024) Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases. 第38屆生物醫學聯合學術年會. 台北 (Oral Speaker)
5. Yu-Hsin Kuan, Meng-Xuan Lin, Shang-En Huang, Jwu-Lai Yeh*. (2023) Bortezomib inhibits proliferation and migration of rat thoracic and pulmonary arterial smooth muscle cells. 第37屆生物醫學聯合學術年會. 台北 (Poster)
6. Jwu-Lai Yeh*, Meng-Xuan Lin, Shang-En Huang, Jong-Hau Hsu. (2023) Xanthine Derivative KMUP-3 Inhibit Osteoclast Differentiation and Porphyromonas gingivalis Lipopolysaccharide-Induced Alveolar Bone Erosion. 19th World Congress of Basic and Clinical Pharmacology (WCP2023). United Kingdom/Glasgow.  (Poster)
7. Kai-Fang Hu*,Chiu-Yen Lin,Hsin-Tien Hsu,Yu-Hsiang Chou,Pei-Feng Liu,Ching-Jiunn Tseng,Jwu-Lai Yeh. (2023) Effect of Glycyrrhetinic Acid Toothpaste on Wound Healing During Periodontal Surgery. 中華民國家庭牙醫學會第十三屆第二次會員大會暨第二十六次學術研討會. 高雄 (Poster)
8. Shang-En Huang, Bin-Nan Wu, Jong-Hau Hsu, Jwu-Lai Yeh*. (2022) In vitro Evaluation of the Anti-inflammatory Effect of KMUP-1 and In vivo Analysis of Its Therapeutic Potential in Osteoarthritis. 第36屆生物醫學聯合學術年會. 台北 (Poster)
9. Shang-En Huang, Jong-Hau Hsu, Hua-Lin Wu, Chao-Han Lai and Jwu-Lai Yeh*. (2021) Recombinant XD123 Inhibits Osteoclastogenesis and Ovariectomy-induced Bone Loss. 第14屆亞太國際藥理學會議.台北 (Poster)
10. Yu-Hsin Kuan, Shang-En Huang, Chao-Han Lai, Jong-Hau Hsu1 and Jwu-Lai Yeh*. (2021) Suppressive Effect of KMUP-1 in a Rat Model of Osteoarthritis. 第14屆亞太國際藥理學會議.台北 (Poster)
11. Pei-Tzu Yen, Shang-En Huang, Lung-Shuo Wang*, Jwu-Lai Yeh*. (2021) Puerarin Protects H9c2 Cardiomyocytes from Lipopolysaccharide-Induced Oxidative Stress and Cardiac Hypertrophy. 第36屆天然藥物研討會.高雄 (Poster)
12. Bin-Nan Wu*, Kan-Ting Yang, Yu-Chi Cheng, Yu-Chin Chang, Jwu-Lai Yeh. (2021) KMUP-1 Restores Large-Conductance Ca2+-Activated K+ Channel Inhibition by Peripheral Nerve Injury in Dorsal Root Ganglia. 第14屆亞太國際藥理學會議.台北 (Poster)
13. Yeh JL*, 張本樺, Huang SE (2020) Xanthine Derivative Suppresses RANKL/Porphyromonas gingivalis Lipopolysaccharide Induced Inflammation and Osteoclast Differentiation. 第35屆天然藥物研討會暨第三屆杜聰明博士醫學論壇. 台北 (Poster)
14. Yeh JL*, Lee ML, Erna Sulistyowati, Hsu JH. (2019) The xanthine derivative against apoptosis in hypoxic-induced rat H9c2 cardiomyocytes. 21st International Hypoxia Symposium. Canada (Poster)
15. Yeh JL*, Huang SE, Hsu JH. (2019) Anti-inflammatory and anti-osteoarthritic effects of the xanthine derivative in osteoarthritis rats. 14th World Congress on Inflammation 2019. Australia/Sydney (Poster)
16. Yeh JL*, Huang SE, Hsu JH. (2019) Anti-inflammatory and anti-osteoarthritic effects of the xanthine derivative KMUP-1 in osteoarthritis rats.  The 34th symposium of natural products. 桃園 (Poster)
17. Yeh JL*, Erna Sulistyowati. (2018) Cardiovascular protective effect of Indonesian herbal medicine in spontaneously hypertensive rats. The 18th World Congress of Basic and Clinical Pharmacology (WCP2018). Japan/KYOTO (Poster presentation)
18. Lee SJ, Widya Yanti Sihotang, Chang YC, Huang WS, Yeh JL*.(2018) Baicalein attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice. The 33th Joint Annual  Conference of Biomedical Science. Taiwan/Taipei (Poster presentation)
19. Yeh JL. (2017) Investigational Glucagon-like Peptide-1 (GLP-1) Receptor Agonists for the Treatment of Pulmonary Arterial Hypertension. The 32th Joint Annual Conference of Biomedical Science. Taiwan/Taipei(Oral Speaker)

指導研究生

校內外榮譽

1. 112-1 課程評量績優(有效平均值 5.40 分（含）以上)
2. 榮獲本校2023年優秀論文獎
3. 榮獲本校2020年優秀論文獎
4. 榮獲本校2019年優秀論文獎
5. 107 學年度專利獲證優良獎
6. 107-2 課程評量績優(有效平均值 5.40 分（含）以上)
7. 106 學年度專利獲證優良獎
8. 105學年度課程評量傑出(有效平均值5.50以上)
9. 105學年度教師教學評量優良(有效平均值5.0~5.249)