研究

1. 梔子苷及其環烯醚萜同類物調控P2嘌呤受體改善第二型糖尿病小鼠誘發神經性疼痛之分子及離子機制研究 (3年)
   國科會112年度專題研究計畫 (112/08/01~115/07/31)
2. 探討銀耳（Tremella fuciformis）預防代謝症候群之功效與藥理機制
   高醫屏科大112年度專題研究計畫 (112/01/01~112/12/31)
3. 山茱萸環烯醚萜苷改善糖尿病鼠痛性神經病變之分子機制及離子通道研究 (3年)
   科技部109年度專題研究計畫 (109/08/01~112/07/31)
4. 馬錢子苷及其同類物改善慢性神經壓迫損傷誘發神經性疼痛之分子機制及離子通道研究(3年)
   科技部106年度專題研究計畫(106/08/01~109/07/31)
5. KMUP-1類似動物保護糖尿病大鼠與db/db小鼠分子機轉研究
   高醫(種子計畫) (106/01/01~106/12/31)
6. 探討茶鹼衍生物對於慢性神經損傷誘發背根神經元BKCa 電流之影響
   NK 高醫-中山合作計畫 (104/01/01~104/12/31)
7. NOS調節劑保護慢性神經損傷誘發神經性疼痛及發炎之分子及細胞機制研究(3年)
   國科會103年度專題研究計畫(101/08/01~104/07/31)
8. 心肺系統血管內皮失能之新治療策略-心肺系統血管內皮失能之新治療策略(2年)
   國科會101年度專題研究計畫(101/08/01~103/07/31)
9. 以坐骨神經損傷後的動物模式探討valproic acid抑制神經性疼痛之效果
   中山高醫101年度合作研究計畫(101/04/16~101/12/31)
10. 天然黃芩類黃酮對抗低氧誘發肺血管功能及離子通道異常研究(3年)
    國科會99年度專題研究計畫(98/08/01~101/07/31)
11. 新型Rho kinase抑制劑對抗野百合鹼、血清素及缺氧誘導肺高壓之分子機制研究(3年)
    國科會99年度專題研究計畫(98/08/01~100/07/31)
12. KMUP-1對抗血清素誘發H9c2心肌細胞肥大保護作用之離子機制
    財團法人屏東基督教醫院研究計畫(100/03/01~101/02/28)

著作

1. Jhuo SJ, Lin YH, Liu IH, Lin TH, Wu BN*, Lee KT, Lai WT. Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor Ameliorate Metabolic Disorder and Obesity Induced Cardiomyocyte Injury and Mitochondrial Remodeling. Int J Mol Sci. 2023 Apr 6;24(7):6842.
2. Tsai WC, Lin YH, Kuo CH, Jhuo SJ, Shih RY, Wu CC, Liu IH, Huang TC, Liu RM, Lin TH, Su HM, Lai WT, Lee CH, Wu BN, Lin SF, Lee HC. Up-regulated small-conductance calcium-activated potassium currents contribute to atrial arrhythmogenesis in high-fat feeding mice. Europace. 2023 Dec 28;26(1):euae004. doi: 10.1093/europace/euae004.
3. Hao CL, Lin HL, Cheng PW, Tu YC, Yeh BC, Wu BN, Shen KP. Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR. J Asian Nat Prod Res. 2023 May;25(5):471-483.
4. Lin RJ, Yen YK, Lee CH, Hsieh SL, Chang YC, Juan YS, Long CY, Shen KP, Wu BN*. Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K+ channels and insulin secretion in pancreatic β cells. Biomed Pharmacother. 2022 Jan;145:112447. 
5. Sulistyowati E, Hsu JH, Lee SJ, Huang SE, Sihotang WY,Wu BN, Dai ZK, Lin MC, Yeh JL. Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo. Int J Mol Sci. 2022 May 18;23(10):5673. 
6. Chen IC, Chen HL, Liu YC, Wu YH, Lo SH, Hsu JH, Yin HL, Hsu JS, Wu BN, Dai ZK. Unique Pulmonary Hypertension in Young Children: A Case Series Study. Children (Basel). 2022 Jul 17;9(7):1064.
7. Hao CL, Lin HL, Cheng PW, Tu YC, Yeh BC, Wu BN, Shen KP. Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR. J Asian Nat Prod Res. 2022 Jul 19:1-13. 
8. Jhuo SJ, Lin TH, Lin YH, Tsai WC, Liu IH, Wu BN, Lee KT, Lai WT. Clinical Observation of SGLT2 Inhibitor Therapy for Cardiac Arrhythmia and Related Cardiovascular Disease in Diabetic Patients with Controlled Hypertension. J Pers Med. 2022 Feb 12;12(2):271. 
9. Cheng KI, Chang YC, Chu LW, Hsieh SL, An LM, Dai ZK, Wu BN*. The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain. Int J Mol Sci. 2022 Dec 14;23(24):15873.
10. Liu YC, Chen YW, Chen IC, Wu YH, Lo SH, Hsu JS, Hsu JH, Wu BN, Cheng YF, Dai ZK. Long-Term Study on Therapeutic Strategy for Treatment of Eisenmenger Syndrome Patients: A Case Series Study. Children (Basel). 2022 Aug 12;9(8):1217.
11. Jhuo SJ, Liu IH, Tasi WC, Chou TW, Lin YH, Wu BN, Lee KT, Lai WT. Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin. Int J Mol Sci. 2021 Jun 5;22(11):6105. 
12. Cheng KI, Chen SL, Hsu JH, Cheng YC, Chang YC, Lee CH, Yeh JL, Dai ZK, Wu BN*. Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. Phytomedicine. 2021 Nov;92:153734. 
13. Hung YC, Liu YC, Wu BN, Yeh JL, Hsu JH. Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats. Front Physiol. 2021 Jul 29;12:661171.
14. Cheng YC, Chiu YM, Dai ZK, Wu BN*. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Cells. 2021 Oct 8;10(10):2688.
15. Lin HL, Cheng PW, Tu YC, Yeh BC, Wu BN, Shen KP. The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR. J Pharm Pharmacol. 2021 Apr 27;73(6):835-845.
16. Huang SE, Sulistyowati E, Chao YY, Wu BN, Dai ZK, Hsu JH, Yeh JL. In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis. Biomedicines. 2021 May 28;9(6):615.
17. Cheng KI, Yang KT, Kung CL, Cheng YC, Yeh JL, Dai ZK, Wu BN*. BKCa Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia. Cells. 2021 Apr 20;10(4):949.
18. Cheng YC, Chu LW, Chen JY, Hsieh SL, Chang YC, Dai ZK, Wu BN*. Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. Cells. 2020 Aug 23;9(9):1948. doi: 10.3390/cells9091948.
19. Chu LW, Cheng KI, Chen JY, Cheng YC, Chang YC, Yeh JL, Hsu JH, Dai ZK, Wu BN*. Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination. Phytomedicine. 2020 Feb;67:153166. doi: 10.1016/j.phymed.2019.153166. 
20. Jhuo SJ, Liu IH, Tsai WC, Lee KT, Wu BN, Lai WT. Effects of Trans, Trans-2,4-decadienal on the Ions Currents of Cardiomyocytes: Possible Mechanisms of Arrhythmogenesis Induced by Cooking-oil Fumes. Sci Rep. 2020 Apr 1;10(1):5771.
21. Long CY, Lin KL, Lee YC, Chuang SM, Lu JH, Wu BN, Chueh KS, Ker CR, Shen MC, Juan YS. Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence. Sci Rep. 2020 Apr 2;10(1):5818. 
22. Shiou YL, Lin HT, Ke LY, Wu BN, Shin SJ, Chen CH, Tsai WC, Chu CS, Lee HC. Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes. J Clin Med. 2019 Jun 20;8(6).
23. Lee ML, Sulistyowati E, Hsu JH, Huang BY, Dai ZK, Wu BN, Chao YY, Yeh JL. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019 Apr 8;24(7).
24. Chen IC, Lin YT, Huang JS, Wu BN, Hsu JH, Tan MS, Dai ZK. Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages. Int J Med Sci. 2019 Feb 28;16(3):443-449. 
25. Chen JY, Chu LW, Cheng KI, Hsieh SL, Juan YS, Wu BN*. Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model. Sci Rep. 2018 Nov 7;8(1):16457.
26. Liu CP, Chau PC, Chang CT, An LM, Yeh JL, Chen IJ, Wu BN*. KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes. Molecules. 2018 Sep 23;23(10). pii: E2433. doi: 10.3390/molecules23102433.
27. Yeh JL, Wu JR, Wu BN, Yang SF, Dai ZK, Liou SF, Hsu JH. B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats. Clin Sci (Lond). 2018 Sep 18;132(18):2045-2058.
28. Sulistyowati E, Lee MY, Wu LC, Hsu JH, Dai ZK, Wu BN, Lin MC, Yeh JL. Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages. Molecules. 2018 Aug 23;23(9). pii: E2124. doi: 10.3390/molecules23092124.
29. Shen KP, Lin HL, Yen HW, Hsieh SL, An LM, Wu BN*. Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats. Kaohsiung J Med Sci. 2018 Mar;34(3):142-149.
30. Lee CH, Dai ZK, Yen CT, Hsieh SL, Wu BN*. KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels. Pharmacol Rep. 2018 Feb 21;70(4):746-752. 
31. Lee YL, Lin KL, Wu BN, Chuang SM, Wu WJ, Lee YC, Ho WT, Juan YS. Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways. Sci Rep. 2018 Mar 29;8(1):5358.
32. Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH, Wu BN*. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells. Chem Biol Interact. 2018 Jan 5;279:171-176. 
33. Chen IC, Tan MS, Wu BN, Chai CY, Yeh JL, Chou SH, Chen IJ, Dai ZK. Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase. Pediatr Pulmonol. 2017 Apr;52(4):443-457. 
34. Lee HC, Chen CC, Tsai WC, Lin HT, Shiao YL, Sheu SH, Wu BN, Chen CH, Lai WT. Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction. Sci Rep. 2017 Sep 21;7(1):12050.

研討會論文

1. Bin-Nan Wu, Jun-Jie Wang, Su-Ling Hsieh, Li-Mei An, Zen-Kong Dai*. (2024) KMUP-1 restores Kv and BKCa channel activities in a rat model of monocrotaline-induced pulmonary arterial hypertension. 第38屆生物醫學聯合學術年會. 台北 (Poster)
2. Yu-Chin Chang, Liang-Jun Wang, Su-Ling Hsieh, Li-Mei An, Bin-Nan Wu*.  (2024) Loganin alleviates diabetic peripheral neuropathy by interfering with pain-related ion channels in dorsal root ganglia. 第38屆生物醫學聯合學術年會. 台北 (Poster)
3. Wu BN*, Chang YC, Hsieh SL, An LM. (2023) Loganin modulates autophagic flux following chronic constriction injury-induced neuropathic pain. 19th World Congress of Basic & Clinical Pharmacology. United Kingdom /Glasgow/Scotland (Poster)
4. Yu-Chin Chang, Su-Ling Hsieh, Li-Mei An, Bin-Nan Wu*. (2023) Loganin Ameliorates Neuropathic Pain Modulating Neuronal Autophagic Flux in a Chronic Constriction Injury Rat Model. 第37屆生物醫學聯合學術年會. 台北 (Poster)
5. Liang-Jun Wang, Jun-Cheng Wu, Yu-Chin Chang, Bin-Nan Wu*. (2023) Loganin Inhibits ATP-Sensitive K+ Channels and Stimulates Insulin Secretion in a Rat Pancreatic β-Cell Line. 第37屆生物醫學聯合學術年會. 台北 (Poster)
6. Jun-Cheng Wu, Su-Ling Hsieh, Yu-Chin Chang, Li-Mei An, Bin-Nan Wu*. (2022) An Iridoid Glycoside Loganin Blocks ATP-Sensitive Potassium Channels and Stimulates Insulin Secretion in β Cell Line RIN-m5F. 第36屆生物醫學聯合學術年會. 台北 (Poster)
7. Yu-Chi Cheng, Yu-Min Chiu, Su-Ling Hsieh, Bin-Nan Wu*. (2022) Loganin Prevents Painful Diabetic Neuropathy by Regulating Oxidative Stress-Mediated Inflammation in Diabetic Rats. 第36屆生物醫學聯合學術年會. 台北 (Poster)
8. Yu-Chin Chang, Su-Ling Hsieh, Li-Mei An, Bin-Nan Wu*. (2022) Loganin Improves Chronic Constriction Injury-Induced Neuropathic Pain by Modulating Neuronal Autophagic Flux. 第36屆生物醫學聯合學術年會. 台北 (Poster)
9. Yu-Chin Chang, Sin-Lan Chen, Su-Ling Hsieh, Chien-Hsing Lee, Bin-Nan Wu*. (2022) Loganin Attenuates Peripheral Nerve Injury-Induced Neuropathic Pain Via CXCL12/CXCR4-Mediated NLRP3 Activation. 第36屆生物醫學聯合學術年會. 台北 (Poster)
10. Jun-Cheng Wu, Rong-Jyh Lin, Yu-Kwan Yen, Chien-Hsing Lee, Kuo-Ping Shen, Bin-Nan Wu*. (2022) Eugenosedin-A Ameliorates Obesity-Related Hyperglycemia by Modulating KATP Channels and Insulin Secretion in Pancreatic β Cells. 第36屆生物醫學聯合學術年會. 台北 (Poster)
11. Shang-En Huang, Bin-Nan Wu, Jong-Hau Hsu, Jwu-Lai Yeh*. (2022) In vitro Evaluation of the Anti-inflammatory Effect of KMUP-1 and In vivo Analysis of Its Therapeutic Potential in Osteoarthritis. 第36屆生物醫學聯合學術年會. 台北 (Poster)
12. Yu-Chi Cheng, Yu-Chin Chang, Su-Ling Hsieh, Bin-Nan Wu*. (2021) Loganin Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Modulating Neuronal Autophagic Flux. 第14屆亞太國際藥理學會議.台北 (Poster)
13. Bin-Nan Wu*, Kan-Ting Yang, Yu-Chi Cheng, Yu-Chin Chang, Jwu-Lai Yeh. (2021) KMUP-1 Restores Large-Conductance Ca2+-Activated K+ Channel Inhibition by Peripheral Nerve Injury in Dorsal Root Ganglia. 第14屆亞太國際藥理學會議.台北 (Poster)
14. Yu-Chi Cheng, Sin-Lan Chen, Yu-Chin Chang, Chien-Hsing Lee, Bin-Nan Wu*. (2021) Loganin Blocks CCI-Induced Neuropathic Pain Through CXCL12/CXCR4 Dependent NLRP3 Inflammasome. 第14屆亞太國際藥理學會議.台北 (Poster)
15. Bin-Nan Wu*, Yu-Chin Chang, Jun-Cheng Wu, Yu-Chi Cheng, Li-Mei An. (2021) Loganin Attenuates Chronic Constriction Injury-Induced Neuropathic Pain by Modulating Excitable Ion Channels in Dorsal Root Ganglia. 第14屆亞太國際藥理學會議.台北 (Poster)
16. Bin-Nan Wu*, Yu-Min Chiu, Yu-Chin Chang, Yu-Chi Cheng, Li-Mei An. (2021) Loganin Alleviates Streptozotocin-Nicotinamide Induced Painful Diabetic Neuropathy Through the NF-κB Signaling Pathway. 第14屆亞太國際藥理學會議.台北 (Poster)
17. Jun-Cheng Wu, Yu-Kwan Yen, Yu-Chin Chang, Kuo-Ping Shen, Bin-Nan Wu*. (2021) Eugenosedin-A Prevents Obesity-Related Hyperglycemia Involved the Regulation of KATP Channels and Insulin Secretion in Pancreatic beta Cells. 第14屆亞太國際藥理學會議.台北 (Poster)
18. Yu-Chi Cheng, Yu-Min Chiu, Su-Ling Hsieh, Bin-Nan Wu*. (2021) An Iridoid Glycoside Loganin Improves Painful Diabetic Neuropathy by Regulating Oxidative Stress-Mediated Inflammation in Diabetic Rats. 第14屆亞太國際藥理學會議.台北 (Poster)
19. Cheng YC, Hsieh SL, Chang YC, Wu BN*. (2020) Iridoid Glycoside Loganin Reduces High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS and NLRP3 Inflammasome. 第35屆天然藥物研討會暨第3屆杜聰明博士醫學論壇. 台北 (Poster)
20. Wu BN*, Hsieh SL, Cheng YC, Chang YC. (2020) Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via TXNIP/NLRP3 Inflammasome axis in nerve-injured rats. The 43rd Annual Meeting of the Japan Neuroscience Society. Japan/Kobe. (Poster)
21. Chen SL, Chu LW, Chang YC, Cheng YC, Hsieh SL, Wu BN*. (2019) Loganin prevents neuropathic pain through the inhibition of NLRP3 inflammasome signaling pathway. The 34th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
22. Chiu YM, Hoang Nguyen Phuong Thao, Chang YC, Cheng YC, Hsieh SL, Wu BN*. (2019) Loganin attenuates neuropathic pain via activating autophagy in chronic constriction injury model. The 34th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
23. Wu BN*, Hsieh SL, Chang YC, Cheng YC. (2019) Loganin protects against chronic constriction injury-induced neuropathic pain by stimulating autophagic functions. The 42nd Annual Meeting of the Japan Neuroscience Society (NEURO2019). Toki Messe, Niigata. (Poster)
24. Wu BN*, Chen SL, Hsieh SL, Chang YC, Cheng YC, Lee CH. (2019) Loganin Improves Neuropathic Pain by Reducing CXCL12/CXCR4-Mediated NLRP3 Inflammasone Activation. 第34屆天然藥物研討會. 桃園 (Poster)
25. Wu BN*, Hsieh SL, Chang YC. Loganin prevents peripheral nerve injury-induced neuropathic pain via the modulation of TNF-α/NF-κB signaling pathway. The 4th Global Chinese Symposium & The 8th Symposium for Cross-straits, Hong Kong and Macao on Free Radical Biology and Medicine. 中國/澳門 (Poster)
26. Wu BN*, Hsieh SL, Yang KT, Kwan AL. (2018) Xanthine derivative KMUP-1 prevents peripheral nerve injury-induced neuropathic pain by restoring the BKCa-channel activity in dorsal root ganglia. 第十一届兩岸三地神經科學研討會. China/桂林. (Poster)
27. Wu BN*, Chang YC, Chu LW, Hsieh SL. (2018) A major iridoid glycoside loganin protects against neuropathic pain via the suppression of TNF-α/NF-κB signaling pathway. 18th World Congress of Basic and Clinical Pharmacology (WCP2018).  Japan/Kyoto. (Poster)
28. Chu LW, Chang YC, Hsieh SL, Chen SL, and Wu BN *. (2018) Loganin improves chronic constriction injury-induced neuroinflammation by inhibiting the TNF-α/NF-κB pathway. The 33th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
29. Chen JY, Chu LW, Wu BN*. (2017) Anti-nociceptive and Anti-inflammatory Activities of Sodium Valproate in Chronic Constriction Injury-Induced Neuropathic Pain in Rats. The 32th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
30. Chu LW, Wang YJ, Hsieh SL, Wu BN*. (2017) KMUP-1 ameliorates neuropathic pain after peripheral nerve injury involved the Nav1.3, Cav2.2 and KATP channel proteins in rat spinal cord.  The 32th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
31. Wu BN*, Hsieh SL, Yang KT. (2017) Restoration of chronic constriction injury-inhibited BKCa channels by a NO activator KMUP-1 in dorsal root ganglia. The 40th Annual Meeting of the Japan Neuroscience Society. Japan/Makuhari Messe. (Poster)

指導研究生

校內外榮譽

1. 榮獲本校111年研究績優教師-優秀論文獎
2. 111-1、2 課程評量績優(有效平均值 5.40 分（含）以上)
3. 榮獲本校2021年優秀論文獎
4. 110-2 學年度課程評量績優 (有效平均值，5.40分(含)以上)
5. 109-2 學年度課程評量績優 (有效平均值，5.40分(含)以上)
6. 榮獲本校2020年優秀論文獎
7. 107-2 課程評量績優(有效平均值 5.40 分（含）以上)
8. 106-1 學年度課程評量傑出(有效平均值5.50)
9. 106 學年度教學優良教師
10. 105 學年度專利獲證優良獎