研究

1. 開發具調節PGC-1 alpha 訊息相關的粒線體生合成、代謝和肌肉激素分泌作用的傳統中藥和天然物以改善骨骼肌和其他器官的功能 (3年) 
   科技部111年度專題研究計畫 (111/08/01~114/07/31)
2. 研發可改善骨骼肌質量，肌力及運動功能之傳統中藥及天然物: 針對高糖、發炎及老化之實驗疾病模式 (3年) 
   科技部108年度專題研究計畫 (108/08/01~111/07/31)
3. 運用智慧電子感官分析系統協助開發具神經保護作用之台產植物芳香組成配方 (3年)
   科技部105年度提升私校研發能量專案計畫(整合型) (105/08/01~108/07/31)
4. 減緩神經退化及增加骨骼肌肌肉蛋白質生成之傳統中藥及天然藥物開發 (3年)
   科技部105年度專題研究計畫 (105/08/01~108/07/31)
5. 神經退化性疾病之多重標的治療藥物開發：傳統中藥、天然物及化學成物 (3年)
   科技部102年度專題研究計畫 (102/08/01~105/07/31)
6. 地黃丸之神經保護作用及機轉探討:建立治療神經發炎及神經退化的傳統中藥開發平台 (3年)
   科技部99年度專題研究計畫 (99/08/01~102/07/31)

著作

1. Chang WH, Hsu HT, Lin CC, An LM, Lee CH, Ko HH, Lin CL, Lo YC*. Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. Int J Mol Sci. 2024 Feb 21;25(5):2514. doi: 10.3390/ijms25052514.
2. Fang WY, Chang WH, Tsai YH, Hsu HT, Chang FR, Lin CL, Lo YC*. Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle. Journal of Food and Drug Analysis. 2023;31(1): 116-136.
3. Chang YC, Lo YC, Chang HS, Lin HC, Chiu CC, Chen YF. An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy. Neurotoxicology. 2023 May; 96:118-128.
4. Hsu HT, Yang YL, Chang WH, Fang WY, Huang SH, Chou SH, Lo YC*. Hyperbaric Oxygen Therapy Improves Parkinson's Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. Biomolecules. 2022 Apr 30;12(5):661.
5. Fang WY, Lin CL, Chang WH, Chang CH, Huang YC, Tsai YH, Chang FR, Lo YC*. Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide. International Journal of Molecular Sciences. 2022 Oct; 23(21):12929.
6. Huang YC, Lin PY, Lee Y, Lee CY, Lo YC, Hung CF, Chen CS. Metabolic syndrome components and leukocyte telomere length in patients with major depressive disorder. World J Biol Psychiatry. 2022 Jul;23(6):483-492.
7. Fang WY, Tseng YT, Lee TY, Fu YC, Chang WH, Lo WW, Lin CL, Lo YC*. Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway. Br J Pharmacol. 2021 Aug;178(15):2998-3016.
8. Lo YC*, Lin CL, Fang WY, Bálint Lőrinczi, István Szatmári, Chang WH, Ferenc Fülöp, Wu SN*. Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K+ Current. Int J Mol Sci. 2021 Jan 28;22(3):1300.
9. Tseng YT, Hsu HT, Lee TY, Chang WH, Lo YC*. Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death. Nutr Neurosci. 2021 Jan;24(1):71-81
10. Huang YC, Lin PY, Yu Lee, Lee CY, Lo YC, Hung CF, Chen CS. Metabolic syndrome components and leukocyte telomere length in patients with major depressive disorder. World J Biol Psychiatry. 2021 Dec 16:1-10.
11. Huang YC, Chang CH, Lin CL, Wang LJ, Hsu CW, Su YF, Lo YC, Hung CF, Hsieh YY, Chen CS. Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease. Int J Environ Res Public Health. 2021 May 18;18 (10):5391
12. Chen YF, Wu SN, Gao JM, Liao ZY, Tseng YT, Fülöp F, Chang FR, Lo YC*. The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. Molecules. 2020 Jun 24;25(12):2907. 
13. Chan MH, Chen HH, Lo YC, Wu SN. Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from Magnolia Officinalis, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K+Current. Int J Mol Sci. 2020 Jun 15;21(12):4260. 
14. Kuo PC, Liu YC, Lo YC, Wu SN. Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids From Croton tonkinensis.Int J Mol Sci. 2020 Feb 13;21(4):1268. 
15. Chang WT, Gao ZH, Li SW, Liu PY, Lo YC, Wu SN. Characterization in Dual Activation by Oxaliplatin, a Platinum-Based Chemotherapeutic Agent of Hyperpolarization-Activated Cation and Electroporation-Induced Currents. Int J Mol Sci. 2020 Jan 8;21(2):396. 
16. Hsu HT, Lo YC*, Wu SN. Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels. Int J Mol Sci. 2020 Feb 20;21(4):1441.
17. Chang WT, Gao ZH, Lo YC, Wu SN. Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by GanodermaTriterpenoids, the Main Active Constitutents ofGanodermaSpores. Molecules. 2019 Nov 22;24(23):4256.
18. Yang CS, Lai MC, Liu PY, Lo YC, Huang CW, Wu SN. Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K+Currents in Pituitary Cells and Hippocampal Neurons. Int J Mol Sci. 2019 Dec 23;21(1):117.
19. Tseng YT, Tsai YH, Fülöp F, Chang FR, Lo YC*. 2-Iodo-4'-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway. Molecules. 2019 Jun 16;24(12).
20. Tseng YT, Hsu HT, Lee TY, Chang WH, Lo YC*. Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death. Nutr Neurosci. 2021 Jan 24(1):71-81.
21. Tseng YT, Chang WH, Lin CC, Chang FR, Wu PC, Lo YC*. Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy. Phytomedicine. 2019 Feb;53:96-106.
22. Tseng YT, Lin WJ, Chang WH, Lo YC*. The novel protective effects of loganin against 1-methyl-4-phenylpyridinium-induced neurotoxicity: Enhancement of neurotrophic signaling, activation of IGF-1R/GLP-1R, and inhibition of RhoA/ROCK pathway. Phytother Res. 2019 Mar;33(3):690-701.
23. Chen HM, Hsiao SM, Kuo MC, Lo YC, Huang MF, Yeh YC, Yen CF, Chen CS. Identifying early decline of daily function and its association with physical function in chronic kidney disease: performance-based and self-reported measures.PeerJ. 2018 Jul 18;6:e5286. doi: 10.7717/peerj.5286.
24. Hsu HT, Tseng YT, Wong WJ, Liu CM, Lo YC.* Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. BMC Complement Altern Med. 2018 Jul 9;18(1):211. 
25. So EC, Wu SN, Lo YC, Su K. Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3). Toxicol Lett. 2018 Mar 15;285:104-112.
26. So EC, Wang Y, Yang LQ, So KH, Lo YC, Wu SN. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. Biochem Pharmacol. 2018 May;151:79-88.
27. Tseng YT, Jong YJ, Liang WF, Chang FR, Lo YC*. The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein. Phytomedicine. 2017 Oct 15;34:97-105.
28. Liu CM, Kao CL, Tseng YT, Lo YC*, Chen CY. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22(9).
29. Hsu HT, Lo YC, Huang YM, Tseng YT, Wu SN. Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells. BMC Neurosci. 2017 Jan 3;18(1):6.

研討會論文

1. Yi-Ching Lo, Yu Fan Chuang, Lin Cheng, Wan-Hsuan Chang, Szu-Yin Yu, Chia-Hung Yen, Fang-Rong Chang. (2024) Anti-atrophic chromene derivative from the twigs of Ficus pumila var. awkeotsang. 7th International Conference and Exhibition on Pharmaceutical Sciences and Technology (PST2024), Chiang Mai, Thailand.(Poster)
2. Yu Fan Chuan, Lin Cheng, Wan-Hsuan Chang, Szu-Yin Yu, Hung-Te Hsu, Fang-Rong Chang, Yi-Ching Lo*. (2024) FPATM-20 protects against methylglyoxal-induced oxidative stress and atrophic factors in C2C12 myotubes.  第三十八屆生物醫學聯合學術年會，Taipei, Taiwan. (Poster)
3. Wan-Hsuan Chang, Yu-Fan Chuang, Hung-Te Hsu, Yi-Ching Lo*. (2024) Protective effects of Guilu Erxian Jiao water extract on diabetic muscle atrophy. 第三十八屆生物醫學聯合學術年會，Taipei, Taiwan. (Poster)
4. Yi-Ching Lo*, Cai-Rong Wu, Wan-Hsuan Chang, Lin Cheng, Yun-Cian Huang, Wei-Yu Fang, Chi-Yu Lu. (2023) Loganin, an iridoid glycoside, attenuates paclitaxel-induced myotube atrophy via improving protein turnover and mitochondrial biogenesis. 19th World Congress of Basic and Clinical Pharmacology (WCP2023)，Glasgow, Scotland, United Kingdom. (Poster)
5. Lin Cheng, Wan-Hsuan Chang, Szu-Yin Yu, Chia-Hung Yen, Fang-Rong Chang, Yi-Ching Lo*. (2023) Spathelichromen attenuates hydrogen peroxide-induced myotube atrophy via inhibiting protein degradation and enhancing antioxidant signaling. 第三十七屆生物醫學聯合學術年會，Taipei, Taiwan. (Poster)
6. Cai-Rong Wu, Wan-Hsuan Chang, Yi-Ching Lo*. (2023) Loganin improves mitochondrial function and glucose homeostasis in a cellular model of chemotherapy-induced muscle atrophy. 第三十七屆生物醫學聯合學術年會，Taipei, Taiwan. (Poster)
7. Wan-Hsuan Chang, Wei-Yu Fang, Lin Cheng, Cai-Rong Wu, Yi-Ching Lo*. (2022) The novel enhancing effects of water extract of Guilu Erxian Jiao on skeletal muscle mass and functions in C57BL/6J mice. The 37th Symposium of Natural Products, Kaohsiung, Taiwan. (Poster)
8. Wan-Hsuan Chang, Wei-Yu Fang, Yueh-Hsiung Kuo, Hung-Te Hsu, Yi-Ching Lo*. (2022) Effects of Ergosta-7,9(11),22-trien-3β-ol on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-Induced Reduction of Skeletal Muscle Mass and Motor Activity in C57BL/6 Mice. 第三十六屆生物醫學聯合學術年會, Taipei, Taiwan. (Poster)
9. Po-Chien Li, Wei-Yu Fang, Wan-Hsuan Chang, Yi-Ching Lo*. (2022) Effects of Gan-Mai-Da-Zao Water Extract on Skeletal Muscle Mass and Function in Aged Mice. 第三十六屆生物醫學聯合學術年會, Taipei, Taiwan. (Poster)
10. Wei-Yu Fang, Cheng Lin, Cai-Rong Wu, Yi-Ching Lo*. (2022) Effects of Loganin on Paclitaxel-Induced C2C12 Myotube Atrophy. 第三十六屆生物醫學聯合學術年會, Taipei, Taiwan. (Poster)
11. Wei-Yu Fang, Yu-Ting Tseng, Tzu-Ying Lee, Yin-Chih Fu, Wan-Hsuan Chang, Wan-Wen Lo, Chih-Lung Lin, Yi-Ching Lo*. (2021) The Effects of Triptolide on Lipopolysaccharide-Induced Skeletal Muscle Atrophy in In Vitro and In Vivo Studies. The 14th Meeting of the Asia Pacific Federation of Pharmacologists (APFP), Taipei, Taiwan. (Poster)
12. Wan-Hsuan Chang, Wei-Yu Fang, Yueh-Hsiung Kuo, Hung-Te Hsu, Yi-Ching Lo*. (2021) The Effects of Ergosta-7,9(11),22-trien-3β-ol on Dopaminergic Neurons and Skeletal Muscle Function in MPTP-Induced Mouse Model of Parkinson's Disease. The 14th Meeting of the Asia Pacific Federation of Pharmacologists (APFP), Taipei, Taiwan. (Poster)
13. Yi-Ching Lo*, Wei-Yu Fang, Wan-Hsuan Chang. (2021) Effects of Water Extract of Guilu Erxian Jiao on Skeletal Muscle Mass, Grip Strength and Motor Activity in C57BL/6J mice. The 14th Meeting of the Asia Pacific Federation of Pharmacologists (APFP), Taipei, Taiwan. (Poster)
14. Hung-Te Hsu, Wan-Hsuan Chang, Wei-Yu Fang, Ya-Lan Yang, Yi-Ching Lo*. (2021) Hyperbaric Oxygen Therapy Reduces the Loss of Dopaminergic Neurons, Improves Locomotion and Enhances Skeletal Muscle Strength in MPTP Mouse Model of Parkinson's Disease. The 14th Meeting of the Asia Pacific Federation of Pharmacologists (APFP), Taipei, Taiwan. (Poster)
15. Wei-Yu Fang, Wan-Hsuan Chang, Po-Chien Li, Cheng Lin, Cai-Rong Wu, Yi-Ching Lo*. (2021) Water Extract of Guilu Erxian Jiao Enhances Protein Synthesis Pathway and Attenuates Methylglyoxal-Induced Myotubes Atrophy. The 36th Symposium of Natural Products, Kaohsiung, Taiwan. (Poster)
16. Fang WY, Zhang ZX, Ferenc Fülöp, Chang FR, Lo YC*. (2020) Synthetic Chalcone Derivative AN07 Attenuates Lipopolysaccharide-Induced Inflammatory and Atrophy Signaling in C2C12 Myotubes. 第35 屆天然藥物研討會暨第三屆杜聰明博士醫學論壇. 台北 (Poster)
17. Chang WH, Lo WW, Chen HT, Ko HH, Wu PC, Lo YC*.  (2019) The Effects of Linalool, A Major Constituent of Essential Oils in Aromatic Plants, on the GABAergic Signaling and Sleep-Wake Cycle in Sprague-Dawley Rats. The 34th Symposium of Natural Products. 桃園. (Poster)
18. Lin CC, Chang WH, Lee TY, Ko HH, Chen CS, Lai CL, Lo YC*.  (2019) Effects of linalool on the dopamine neurons and motor symptoms in experimental models of Parkinson's disease. 第34屆生物醫學聯合學術年會. 台北. (Poster)
19. Lo YC, Tseng YT, Chang WH, Lin CC. (2018) Liuwei dihuang water extract prevents skeletal muscle atrophy in streptozotocin-induced diabetic mice. The 4th Global Chinese Symposium & The 8th Symposium for Cross-straits, Hong Kong and Macao on Free Radical Biology and Medicine. 中國/澳門. (Poster)
20. Tseng YT, Lin CC, Chang FR, Lo YC*. (2018) 2-iodo-4’-methoxychalcone protects neurons against methylglyoxal-induced oxidative stress.  The 33th Joint Annual Conference of Biomedical Sciences. Taiwan/Taipei. (Poster)
21. Tseng YT, Lo YC *, Liu CM, Hung-Te Hsu, Pao-Chu Wu. (2018) Protective effects of the water extract of Liuwei dihuang on methylglyoxal-induced atrophy in myotubes. WCP 2018.Japan/Kyoto. (Poster)
22. Lo YC *, Wu SN, Chang WH, Tseng YT, Ko HH. (2018) Effects of D-limonene on neurotropic factors and ionic currents in the olfactory nerve cells Rolf B1.T. WCP 2018. Japan/Kyoto. (Poster)
23. Lo YC, Tseng YT.(2017) Liuwei dihuang, a traditional Chinese medicine, attenuates methylglyoxal-induced activation of oxidative stress and protein degradation in C2C12 skeletal muscle myotubes. 10th Asia-Pacific Pharma Congress. Singapore  (Poster) 

指導研究生

校內外榮譽

1. 榮獲112年度高醫藥學文教基金會第11屆傑出校友

2. 112學年「教師教學評量」績優 (有效加權平均值大於等於5.66分)
3. 榮獲本校2023年研究成果績優獎
4. 111學年「教師教學評量」績優 (有效加權平均值大於等於5.61分)
5. 111-2 學年度課程評量績優 (有效平均值，5.40分(含)以上)
6. 110-1 學年度課程評量績優 (有效平均值，5.40分(含)以上)
7. 110-2 學年度課程評量績優 (有效平均值，5.40分(含)以上)
8. 110學年「教師教學評量」績優 (有效加權平均值大於等於5.61分)
9. 榮獲本校2021年研究成果績優獎
10. 榮獲本校2021年優秀論文獎
11. 榮獲本校2020年研究成果績優獎
12. 榮獲本校2020年優秀論文獎
13. 108學年度教師教學評量績優
14. 108-1 學年度課程評量績優 (有效平均值，5.40分(含)以上)
15. 108-2 學年度課程評量績優 (有效平均值，5.40分(含)以上)
16. 榮獲本校2019年優秀論文獎
17. 榮獲本校2019年研究成果績優獎
18. 107 年度研究成果績優獎一般教師組
19. 107學年度「教學優良教師」
20. 107學年度技術移轉優良獎
21. 106 年度研究成果績優獎一般教師組
22. 106 年度研究績優教師
23. 106-2 學年度教師課程評量傑出 (有效平均值5.50(含)以上)
24. 105 學年度研究績優教師
25. 105 學年度課程評量傑出(有效平均值5.50以上)
26. 105 學年度教師教學評量傑出(有效平均值5.50(含)以上)