研究

著作

1. Chuang JM, Chen HL, Chang CI, Lin JS, Chang HM, Wu WJ, Lin MY, Chen WF, Lee CH*. Nobiletin derivative, 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia. Immunopharmacol Immunotoxicol. 2024 May 27:1-15.
2. Chang WH, Hsu HT, Lin CC, An LM, Lee CH, Ko HH, Lin CL, Lo YC. Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. Int J Mol Sci. 2024 Feb 21;25(5):2514. doi: 10.3390/ijms25052514.
3. Lin CL, Yu CI, Lee TH, Chuang JM, Han KF, Lin CS, Huang WP, Chen JY, Chen CY, Lin MY, Lee CH*. Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction. Phytomedicine. 2023 Mar;111:154655. 
4. Chien-Hsing Lee#, Shih-Ya Hung*. Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders. Pharmaceutics. 2022 Dec 22;15(1):31. 
5. Lee CH, Tsai HY, Chen CL, Chen JL, Lu CC, Fang YP, Wu DC, Huang YB, Lin MW. Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation. Biomedicines. 2022 Jun 8;10(6):1350. 
6. Chen WF, Shih YH, Liu HC, Cheng CI, Chang CI, Chen CY, Lin IP, Lin MY, Lee CH*. 6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. Phytomedicine. 2022 Mar 1;99:154025. 
7. Chen HL, Lo YH, Lin CL, Lee TH, Leung W, Wang SW, Lin IP, Lin MY, Lee CH*. Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling. Biomed Pharmacother. 2022 Sep;153:113351. 
8. Lin RJ, Yen YK,Lee CH, Hsieh SL, Chang YC, Juan YS, Long CY, Shen KP, Wu BN. Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K+ channels and insulin secretion in pancreatic β cells. Biomed Pharmacother. 2022 Jan;145:112447.
9. Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH*. Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer. Biochem Pharmacol. 2021 Feb;184:114403.
10. Hung SY, Chen WF, Lee YC, Su JH, Juan YS, Lin IP, Zhang YH, Chang MK, Lin MY, Chen CY,Lee CH*. Rhopaloic acid A induces apoptosis, autophagy and MAPK activation through ROS-mediated signaling in bladder cancer. Phytomedicine. 2021 Nov;92:153720.
11. Chen HL, Su YC, Chen HC, Su JH, Wu CY, Wang SW, Lin IP, Chen CY, Lee CH*. Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin. Biomedicines. 2021 Aug 29;9(9):1109.
12. Yu CI, Cheng CI, Kang YF, Chang PC, Lin IP, Kuo YH, Jhou AJ, Lin MY, Chen CY, Lee CH*. Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway. Neurotox Res. 2020 Jun;38(1):163-174.  
13. LSW, Lee CH, Lin MS, Chi CW, Chen YJ, Wang GS, Liao KW, Chiu LP, Wu SH, Huang DM, Chen L, Shen YS.  ZnO Nanoparticles Induced Caspase-Dependent Apoptosis in Gingival Squamous Cell Carcinoma through Mitochondrial Dysfunction and p70S6K Signaling Pathway. Int J Mol Sci. 2020 Feb 26;21(5):1612. 
14. Tai HC, Lee TH, Tang CH, Chen LP, Chen WC, Lee MS, Chen PC, Lin CY, Chi CW, Chen YJ, Lai CT, Chen SS, Liao KW, Lee CH, Wang SW. Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells. Mar Drugs. 2019 Apr 6;17(4).
15. Lee CH, Huang CW, Chang PC, Shiau JP, Lin IP, Lin MY, Lai CC, Chen CY. Reactive oxygen species mediate the chemopreventive effects of syringin in breast cancer cells. Phytomedicine. 2019 Jan 28;61:152844. 
16. Lin CL, Jeng JH, Wu CC, Hsieh SL, Huang GC, Leung W, Lee CT, Chen CY, Lee CH*. Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats. Biomed Res Int. 2017;2017:3634915.
17. Lee CH, Dai ZK, Yen CT, Hsieh SL, Wu BN. KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels. Pharmacol Rep. 2018 Feb 21;70(4):746-752.
18. Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH, Wu BN. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells. Chem Biol Interact. 2018 Jan 5;279:171-176.
19. Kuo CN, Chen CH, Chen SN, Huang JC, Lai LJ, Lai CH, Hung CH, Lee CH*, Chen CY. Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization. Int Ophthalmol. 2017 Apr 9. doi: 10.1007/s10792-017-0530-6.

研討會論文

1. Hui-Min Chang, Wan-Ju Wu, Chien-Hsing Lee*. (2024)The antimicrobial peptide HUC induced the apoptosis of bladder cancer through SIRT1/PGC-1α signaling pathway. 第38屆生物醫學聯合學術年會. 台北 (Poster)
2. Yuan-Wu Shao, Tzu-Yu Chiu, Ho-Cheng Wu, Andrea Gu, Yu-Fan Chuang, Chien-Hsing Lee, Yi-Ching Lo, George Hsiao, Fan-Li Lin*. (2023) The extracts of Oleaceae family affect retinal pigment epithelial cell activities. 第38屆天然藥物研討會-從歷史中洞察天然物(Poster)
3. 林雨彤,李建興*. (2023) Compound YT Induced Ferroptosis to Inhibit Proliferation of Oral Squamous Cell Carcinomas. 第37屆生物醫學聯合學術年會. 台北 (Poster)
4. Jun-Cheng Wu, Rong-Jyh Lin, Yu-Kwan Yen, Chien-Hsing Lee, Kuo-Ping Shen, Bin-Nan Wu*. (2022) Eugenosedin-A Ameliorates Obesity-Related Hyperglycemia by Modulating KATP Channels and Insulin Secretion in Pancreatic β Cells. 第36屆生物醫學聯合學術年會. 台北 (Poster)
5. Yu-Chin Chang, Sin-Lan Chen, Su-Ling Hsieh, Chien-Hsing Lee, Bin-Nan Wu*. (2022) Loganin Attenuates Peripheral Nerve Injury-Induced Neuropathic Pain Via CXCL12/CXCR4-Mediated NLRP3 Activation. 第36屆生物醫學聯合學術年會. 台北 (Poster)
6. An-Jie Jhou, Wan Ping Huang, Chen-Hsing Lee*. (2021) Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.  第14屆亞太國際藥理學會議.台北 (Poster)
7. Wan Ping Huang, Chien-Hsing Lee*. (2021) WP1 induces endoplasmic reticulum stress -mediated apoptosis through ROS in chemoresistant oral cancer.  第14屆亞太國際藥理學會議.台北 (Poster)
8. Yu-Chi Cheng, Sin-Lan Chen, Yu-Chin Chang, Chien-Hsing Lee, Bin-Nan Wu*. (2021) Loganin Blocks CCI-Induced Neuropathic Pain Through CXCL12/CXCR4 Dependent NLRP3 Inflammasome. 第14屆亞太國際藥理學會議.台北 (Poster)
9. Ya-Hui Zhang, Chien-Hsing Lee. (2021) YH1 induced apoptosis of oral cancer through autophagy. 第14屆亞太國際藥理學會議.台北 (Poster)
10. Wu BN*, Chen SL, Hsieh SL, Chang YC, Cheng YC, Lee CH. (2019) Loganin Improves Neuropathic Pain by Reducing CXCL12/CXCR4-Mediated NLRP3 Inflammasone Activation. 第34屆天然藥物研討會. 桃園(Poster)
11. Lee CH*, Chen CH, Chen CY*, Kuo CN*. (2018) Antioxidant mechanisms of dexamethasone and triamcinolone acetonide in LPS-treated human retinol epithelium ARPE-19 cells. The 4th Global Chinese Symposium & The 8th Symposium for Cross-straits, Hong Kong and Macao on Free Radical Biology and Medicine. 中國/澳門 (Poster)
12. Lee CH*. Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization. 18th World Congress of Basic and Clinical Pharmacology (WCP2018). 日本/京都 (Poster)

指導研究生

校內外榮譽