研究

著作

1. Wu LH, Cheng YW, Lin FL, Hsu KC, Wang MH, Yen JL, Wang TJ, Lin TE, Liu YC, Huang WJ, Hsiao G. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress. Biomed Pharmacother. 2024 May;174:116538.
2. Yu-Fan Chuang, Fan-Li Lin. (2023) Oxygen-Induced Retinopathy in the Rat: An Animal Model to Study the Proliferative Retinal Vascular Pathology. Methods Mol Biol. 2023; 2678:27-36. 
3. Wang, J.H.†, Lin, F.L. ^†, Chen, J.Y., Zhu, L.X., Chuang, Y.F., Tu, L.L., Ma, C.K., Ling, D., Hewitt A.W., Tseng, C.L., Shah, M.H., Bui, B., Wijngaarden P.V., Dusting, G.J., Wang P.Y., *Liu, G.S. (2022) TAK1 blockade as a therapy for retinal neovascularization. Pharmacological Research 187:106617 (SCI, IF=10.334, ranking = 5.4% in Pharmacology & Pharmacy). 
4. Lin, F.L., Cheng, Y.W. ^†, Chen L.H., Ho, J.D., Yen, J.L, Wang, M.H., Lee, T.H.^†, and Hsiao, G.^† (2022) Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity. Biomedicine & Pharmacotherapy 158:114138 (SCI, IF=7.419, ranking = 9.3% in Pharmacology & Pharmacy)
5. Wang, J.H.^†, Tseng, C.L.^†, Lin, F.L., Chen, J.Y., Hsieh, E.H., Lama, S., Chuang, Y.F., Kumar, S., Zhu, L.X., McGuinness, M.B., Hernandez, J., Tu, L.L, Wang, P.Y., Liu, G.S*. (2022) Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization. Theranostics 12(2): 657-674 (SCI, IF=11.629, ranking = 6.4% in Medicine, Research & Experimental)
6. Chuang, Y.F. ^†, Wang, J.H. ^†, Chen, J.Y., Singh, V., Charlesworth, J.C., Tu, L.L., Lin, F.L., Riaz, M., Li, F., Bui, B.V., Wong, R.C.B., Wang, P.Y., Zhong, J.X., Hewitt, A.W., Wijngaarden, P.V., Dusting, G.J., Liu, G.S. (2022) An integrative multi-omics analysis reveals microRNA-143 as potential therapeutics to attenuate retinal angiogenesis. Nucleic Acid Therapeutics 32(4):251-266. (SCI, IF=4.521, ranking = 15.9% in Chemistry, Medicinal)
7. Hsu, T.J., Nepali, K., Tsai, C.H., Imtiyaz, Z., Lin, F.L., Hsiao, G., *Lai, M.J., *Cheng, Y.W. (2021) HDAC/HSP90 inhibitor G570 attenuated blue-light and oxidative stress mediated migration in RPE cells and neovascularization in mice through decreased VEGF production. Molecules 26(14), 4359 (SCI, IF = 4.588, ranking = 35.4% in Chemistry, multidisciplinary)
8. Chuang, Y.F., Wang P.Y., Kumar S.S., Lama S., Lin, F.L., *Liu, G.S. (2021) Methods for in vitro CRISPR/CasRx-mediated RNA-editing. Frontiers Cell Dev Biol 667879 (SCI, IF=7.219, ranking = 14.6% in Developmental Biology)
9. Hsueh, P.J., Wang, M.H., Hsiao, C.J., Chen, C.K., Lin, F.L., Huang, S.H., Yen, J.L., Tsai, P.H., *Kuo, Y.H., *Hsiao G. (2021) Ergosta-7,9(11),22-trien-3β-ol alleviates intracerebral hemorrhage-induced brain injury and BV-2 microglial activation. Molecules 26, 2970 (SCI, IF=4.588, ranking = 35.4% in Chemistry, multidisciplinary)
10. Chuang, Y.F., Phipps A.J., Lin, F.L., Hecht V., Hewitt A.W., Wang P.Y., *Liu, G.S. (2021) Approach for In vivo Delivery of CRISPR/Cas System: A Recent Update and Future Prospect. Cell Mol Life Sci 78, 2683–2708 (SCI, IF=9.074, ranking = 10.1% in Biochemistry & Molecular Biology)
11. Chan, Y.J., Liao, P.L., Tsai, C.H., Cheng, Y.W., Lin, F.L., Ho, J.D., Chen, C.Y., *Li, C.H. (2021) Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation. Part Fibre Toxicol 18,4 (SCI, IF=9.642, ranking = 3.2% in Toxicology)
12. Lin, F.L., Wang, P.Y., Chuang, Y.F., Wang, J.H., Wong, V.H.Y., Bui, B.V., *Liu, G.S. (2020) Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update. (Review article) Mol. Ther. S1525-0016(20)30341-5 (SCI, IF=11.249, ranking =3.8% in Biotechnology & Applied Microbiology, First Author)
13. Chen, J.Y., Lin, F.L., Leung, J.Y. K., Tu, L.L., Wang, J.H., Chuang, Y.F., Li, F., Shen, H.H, Dusting, G.J., Wong, V.H.Y., Lisowski, L., Hewitt, A.W., Bui B.V., Zhong, J.X., *Liu, G.S. (2020) A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization. Angiogenesis 24, 97-110 (SCI, IF=8.689, ranking = 6.2% in Peripheral Vascular Disease)
14. Jan, J.S., Yang, C.H., Wang, M.H., Lin, F.L., Yen, J.L., Hsieh, Irene, Khotimchenko M., Lee, T.H.,  *Hsiao G. (2019) Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury. Mar. Drugs 17(6), 360 (SCI, IF=5.5951, ranking=19.0% in Chemistry, Medicinal)
15. Lin, F.L., Cheng, Y.W., Yu, M., Ho, J.D., Chiou G.C.Y., Chang, H.M., Lee, T.H., *Hsiao, G. (2019) The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition. Phytomedicine 56, 207-214 (SCI, IF=5.161, ranking=10.3% in Integrative & Complementary Medicine, First Author)
16. Lin, F.L., Yen, J.L., Kuo, Y.C., Cheng, Y.W., Huang, W.J., *Hsiao, G. (2019) HADC8 inhibitor WK2-16 therapeutically targeted lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation. Int J Mol Sci 18;20 (2) (SCI, IF=6.132, ranking=22.6% in Biochemistry & molecular biology, First Author
17. Lee, Y.L., Hsiao, C.J., Lin, F.L., Jan, J.S., Chou, Y.C., Lin, Y.Y., Chen C.K., Lam. K.K., *Hsiao, G. (2018) Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells. Mediators Inflamm 2018: 9541459. (SCI, IF=5.340, ranking=42.0% in Immunology)
18. Lin, F.L., Ho, J.D., Cheng, Y.W., Chiou G.C.Y., Yen J.L., Chang, H.M., Lee, T.H., *Hsiao, G. (2018) Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation. Front Pharmacol 9:326 (SCI, IF=6.006, ranking=14.5% in Pharmacology & Pharmacy, First Author)
19. Lin, C. H., Wu, M. R., Li, C. H., Cheng, H. W., Huang, S. H., Tsai, C. H., Lin, F.L., Ho, J. D., Kang, J. J., Hsiao, G., *Cheng, Y. W. (2017) Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis. Toxicol Sci 157, 196-210 (SCI, IF=4.996, ranking=21.5% in Toxicology)
20. Lin, F.L., Lin, C. H., Ho, J. D., Yen, J. L., Chang, H. M., Chiou, G. C., Cheng, Y. W., *Hsiao, G. (2017) The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration. Sci Rep 7, 41086 (SCI, IF=5.134, ranking=23.3% in Multidisciplinary Sciences, First Author)
21. Lin, C. H., Liao, P. L., Hsiao, G., Li, C. H., Huang, S. H., Tsai, C. H., Wu, M. R., Lin, F.L., Ho, J. D., Cheng, H. W., *Cheng, Y. W. (2015) Long-term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed With Optical Coherence Tomography. Toxicol Sci 147, 317-325 (SCI, IF= 4.996, ranking=21.5% in Toxicology)
22. Lin, F.L., Shen, H.W. (2013) Review: Prevention of cardiovascular disease in women. The Journal of Taiwan Pharmacy 29, No.4 (台灣藥學雜誌)
23. Chou, Y. C., Sheu, J. R., Chung, C. L., Chen, C. Y., Lin, F.L., Hsu, M. J., Kuo, Y. H., *Hsiao, G. (2010) Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells. Chem Biol Interact 184, 403-412 (SCI, IF=3.057, ranking=17.4% in Cell Biology)

研討會論文

1. Tzu-Yu Chiu, Yuan-Wu Shao, Ho-Cheng Wu, Andrea Gu, Fan-Li Lin*. The regulatory profile of Oleaceae methanolic extracts in retinal pigment epithelium. 2024 The 38th Joint Annual Conference of Biomedical Science.
2. Lin, F.L., Wu, L.H., Yen, J.L., Wang, T.J., Cheng, Y.W., & Hsiao, G. Aryl Hydrocarbon Receptor Agonist FICZ Impedes Retinal Pathogenesis in Glucomatous Mice. 2023 The 37th Joint Annual Conference of Biomedical Science
3. Lin, F.L., Chen, L.D., Ho, J.D., Wu, L.H., Kuo, Y.H., Cheng, Y.W. & Hsiao, G. Fungal Ingredient 3,4-Dihydroxybenzalacetone Protect Against Blue Light-Emitting Diode Light-induced Retinal Photoreceptor Cell Damage and Degeneration in Vivo. 2022 The 36th Joint Annual Conference of Biomedical Science
4. Lin, F.L., Cheng, Y.W., Chen, L.H., Ho, J.D., Yen, J.L., Wang M.H., Lee, T.H., & Hsiao, G. The natural compound theissenolactone B protects against retinal degeneration in a sodium iodate-induced model of AMD mediated by sequestering MMP-9 in the RPE and anti-microglia activities. 2022 The 37th Symposium of Natural Products
5. Lin, F.L., Chen, L.H., Ho, J.F., Wu, L.H., Kuo, Y.H., Cheng, Y.W. & Hsiao, G. The Protective Effects and Mechanisms of Fungal Ingredient 3,4-Dihydroxybenzalacetone against Blue Light-Emitting Diode Light-induced Retinal Photoreceptor Cell Damage and Degeneration in Vivo. 2021 Asia Pacific Federation of Pharmacologists (APFP) Poster-E049
6. Chen, C.K., Cheng, Y.W., Lin, F.L., Chou, Y.C., Wang, M.H., Chen, C.H., Lee, Y.C., Hsu, K.C., Chien, M.H., Lee, T.H., & Hsiao, G. A Novel Small Fungal Molecule, Theissenolactone C, Inhibits Lipopolysaccharide-induced TAK-1/IKK Signaling and Improves Endotoxemic Injuries in Vivo. 2021 Asia Pacific Federation of Pharmacologists (APFP) Poster-I019
7. Do, A.P., Chen, C.K., Lin, F.L., Yen, J.L., Jan, J.S., Hsiao, T.C., Hsu, S.P. & Hsiao G. Benzydamine Attenuates Liposaccharide-induced Matrix Metalloproteinase-9 Activation in Human monocytic Cells by Inhibition of ERK-MAPK. 2021 Asia Pacific Federation of Pharmacologists (APFP) Poster-B020
8. Chen, C.Y., Tsai, C.H., Yang, T.M., Lin, F.L., Hsiao, G., Liu, Y.M., Liou, J.P., Cheng, Y.W. The potential application of aroylindoline derivatives small molecular compounds on blue light-induced retinopathy. 2020 World Ophthalmology Congress
9. Chen, J.Y., Leung, J., Lin, F.L., Tu, L.L., Wang, J.H., Chuang, Y.F., Bui, B., Wong, V., Lisowski, L., Hewitt, A., Zhong, J.X., Liu, G.S. Switchable gene therapy for controlled intervention in ocular neovascularization. ARVO 2020 Annual Meeting
10. Lin, F.L., Hsiao, G, Yen, J.L.,Kuo, Y.C., Cheng, Y.W., Huang W.J.,Kang, J.J. Novel HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-induced Mouse Model of Neuroinflammation and Microglial Activation through Downregulation of STAT Signaling. 2019 The 34th Joint Annual Conference of Biomedical Science
11. Lin, F.L., Kang, J.J., Yen, J.L.,Ho, J.D., Huang, C.Y., Cheng, Y.W., Hsiao, G. Selective Blockade of HDAC8 by BMX Attenuates Laser-Induced Choroidal Neovascularization Model in Mice. 2019 The 34th Joint Annual Conference of Biomedical Science
12. Lin, F.L., Ho, J.D., Cheng, Y.W., Lee, T.H. & Hsiao, G. Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation. 2018 The 33th Joint Annual Conference of Biomedical Science
13. Yu, M., Lin, F.L., Jan, J.S., Cheng, Y.W., Lee, T.H. & Hsiao, G. The investigation of inhibitory mechanisms of LC53 on monocytic matrix metalloproteinase-9 expression and its protective effects of retinal degeneration. 2017 The 32th Joint Annual Conference of Biomedical Science
14. Lin, F.L., Lin, C.H., Ho, J.D., Yen, J.L., Chang, H.M., Chiou, G.C., Cheng, Y.W. & Hsiao, G. The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degeneration. 2017 The 32th Joint Annual Conference of Biomedical Science (Oral present, #O28)
15. Lin, C. H., Wu, M. R., Li, C. H., Cheng, H. W., Huang, S. H., Tsai, C. H., Lin, F.L., Ho, J. D., Kang, J. J., Hsiao, G., and Cheng, Y. W. Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis. 2017 The 32th Joint Annual Conference of Biomedical Science (Oral present, #O67)
16. Lin, F.L., Ho, J.D., Cheng, Y.W., Lee, T.H. & Hsiao, G. Neuroprotective effect of a natural compound, LC53, in a rat model of ocular inflammation. 2017 Teachers and Students Joint Academic Research Symposium of TMU
17. Lin, F.L., Yen, J.L., Chou, Y.C., Jan, J.S., Lin, C.H., Cheng, Y.W., Huang, W.J., and Hsiao, G. A novel HDAC8 inhibitor, HHJ-16, suppresses microglial activation and neuroinflammation in vitro and in vivo. 2016 The 31^th Joint Annual Conference of Biomedical Science
18. Lin, F.L., Yen, J.L., Lin, C.H., Ho, J.D., Cheng, Y.W., and Hsiao, G. A natural retinoprotectant, Chrysophanol, attenuated N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis and retinopathies. 2016 International Conference on Engineering and Natural Science
19. Chiang, H.T., Lin, F.L., Yen, J.L., Chou, Y.C., and Hsiao, G. The protective effects of carprofen in various animal models of encephalopathy. 2015 The 30th Joint Annual Conference of Biomedical Science.
20. Lin, F.L., Lin, C.H., Liao, P.L., Yen, J.L., Ho, J.D., Cheng, Y.W., and Hsiao, G. Chrysophanol blocked N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis and attenuated neuroinflammatory responses via microglial inhibition. 2015 International Conference on Engineering and Applied Sciences

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